Pulmonary Arterial Hypertension

About

Pulmonary arterial hypertension (PAH) is a chronic and life-threatening disease characterised by progressive vascular remodelling that leads to increased pulmonary vascular resistance, right ventricular heart failure and death.

PAH is defined by >25 mmHg increase in pulmonary arterial blood pressure and a pulmonary capillary wedge pressure of 15 mmHg. If left untreated, PAH is fatal; it has a survival rate of just 34% after 5 years. Current therapies include stimulating the nitric oxide (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine monophosphate (cGMP) axis, improving the prostacyclin pathway or inhibiting the endothelin pathway.

Related Articles

Articles

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Treatment Selection in Pulmonary Arterial Hypertension: Phosphodiesterase…

Hiroshi Watanabe,

Citation: European Cardiology Review 2018;13(1):35–7.

Direct Oral Anticoagulants: A Quick Guide

Julia Sikorska, James Uprichard,

Citation: European Cardiology Review 2017;12(1):40–5.

A Practical Clinical Approach to the Diagnosis and Treatment of Patients…

Brendan P Madden,

Citation: European Cardiology Review 2015;10(2):102–7

Pulmonary Hypertension

Brendan P Madden,

Citation: European Cardiology Review 2015;10(1):9–11