Hypertension is the most common modifiable risk factor for cardiovascular disease and death, and lowering blood pressure with antihypertensive drugs reduces target organ damage and prevents cardiovascular disease outcomes.

Most hypertensive patients will need a combination of antihypertensive agents to achieve the therapeutic goals. Recent guidelines recommend initiating treatment with two drugs in those patients with a systolic blood pressure >20 mmHg and/or a diastolic blood pressure >10 mmHg above the goals, and in those patients with high cardiovascular risk. In addition, approximately 25% of patients will require three antihypertensive agents to achieve the therapeutic targets.


Network Meta-analysis to Determine the Optimal Level of Systolic Blood Pressure for Hypertensive Patients


European Cardiology Review 2020;15:e24.

Blood Lead Level and Hypertension Risk in the United States National Health Nutrition and Examination Survey (NHANES) 1999–2016


European Cardiology Review 2020;15:e36.

Hypotensive Action of Melatonin in Patients with Arterial Hypertension


European Cardiology Review 2020;15:e43.

Are Antihypertensives a Risk Factor for Cancer?


30 April 2020


European Cardiology Review 2020;15:e21.