This issue of European Cardiology Review features articles of major practical relevance as well as reviews and expert opinions on topics of pathophysiological importance. J Dungu reviews diagnostic and prognostic issues regarding cardiac amyloid highlighting the importance of imaging for the diagnosis and management of the condition. M Sheppard gives a pathologist’s perspective on stress cardiomyopathy while D Lerman et al’s manuscript focuses on the clinical implications of aortic calcification. A current issue that is of major interest i.e. sleep-disordered breathing in heart failure, is tackled by SG Pearse et al. One of the sections of the current issue has been devoted to systemic and pulmonary hypertension, featuring important contributions by B Madden on practical diagnostic pathways in pulmonary hypertension and J George et al on the importance of home blood pressure monitoring. The problems of which NOAC to use in clinical practice and the management of anticoagulation in high bleeding risk patients are addressed by G Dan. The myocardial infarction session features a scholarly review on MINOCA by S Pasupathy et al and there are also two other important manuscripts, one authored by R Liew et al on the topic of Sudden Cardiac Death Risk Stratification and the second one by V Batchvarov on Inter-Atrial Conduction Block, a recently reported novel syndrome. Last but not least, an original research article by S Podd et al. on Home Orthostatic Training In Elderly Patients With Vasovagal Syncope closes the current issue, objectively assessing the role of orthostatic training in the elderly for prevention of vasovagal syncope. We hope that this issue of European Cardiology Review will assist the reader in getting insight into the diagnosis and management of frequent and complex conditions affecting the cardiovascular system.