Omega-6 Polyunsaturated Fatty Acid Levels and Delirium in Patients With Acute Cardiovascular Disease

Register or Login to View PDF Permissions
Permissions× For commercial reprint enquiries please contact Springer Healthcare:

For permissions and non-commercial reprint enquiries, please visit to start a request.

For author reprints, please email
Average (ratings)
No ratings
Your rating
Copyright Statement:

The copyright in this work belongs to Radcliffe Medical Media. Only articles clearly marked with the CC BY-NC logo are published with the Creative Commons by Attribution Licence. The CC BY-NC option was not available for Radcliffe journals before 1 January 2019. Articles marked ‘Open Access’ but not marked ‘CC BY-NC’ are made freely accessible at the time of publication but are subject to standard copyright law regarding reproduction and distribution. Permission is required for reuse of this content.

Topic: Preventive Medicine


Delirium frequently occurs in patients admitted to the intensive care unit and is associated with mortality and morbidity. Although several studies reported associations between polyunsaturated fatty acids (PUFAs) and cognitive disorders, the association between PUFAs and delirium in patients with acute cardiovascular disease remains unknown.

Methods and Results

We enrolled 589 consecutive patients (mean age: 70 ± 14 years) admitted to the coronary care unit of Juntendo University Hospital from January 2015 to December 2016. Fasting serum PUFA levels were measured within 24 hours of admission. Delirium was defined as patients with a delirium score ≥4 using the Intensive Care Delirium Screening Checklist. Delirium was present in 54 patients. The levels of dihomo-gamma-linolenic acid (DGLA) was significantly lower in patients with delirium than in those without delirium (DGLA: 23.1 ± 10.3 versus 31.4 ± 12.6 μg/ml, p<0.0001), whereas AA and omega-3 PUFAs did not differ between the two groups. In addition, DGLA and AA, but not omega-3 PUFA, were negatively associated with the delirium score (DGLA: p<0.0001; AA: p=0.002).


Low omega-6 PUFA levels on admission were significantly associated with delirium in the coronary care unit, indicating that low omega-6 PUFA levels may identify patients at high risk of developing delirium.