ESC 23: Hot Line & Late-breaking Science Video Collection

Published: 04 August 2023

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Overview

What's hot at the European Society of Cardiology (ESC) Congress 2023?

Browse our curated coverage of the latest updates in cardiology from Amsterdam.

  • Watch our View From the Thoraxcenter series for a concise line up of the most awaited trials from Prof Nicolas Van Mieghem and Dr Joost Daemen. 
  • For a deeper dive into key clinical trial data and its applicability, host, Dr Harriette Van Spall meets with Principal Investigators in her Late-Breaker Discussion series.
  • View a condensed summary of the crucial takeaways from each day in our Wrap-Up series with Dr Mirvat Alasnag.
  • Our short, accessible Expert Interviews with select faculty focus on data, patient care and the future of their field.
  • We will feature personal perspective in Behind the Heart series focusing on career pathways, personal motivations and perspectives on the field.

More from this programme

Part 1

View From the Thoraxcenter

2 sessions
ESC 23 Late-breaking Science Wrap Up Watch now
ESC 23 Late-breaking Science Preview Watch now

Part 2

Late-Breaker Discussions with Dr Harriette Van Spall

4 sessions
The ECLS-Shock Trial Watch now
The STEP HFpEF Trial Watch now
The RECORD MI Registry Watch now
Heart Failure at ESC 2023: Recapitulations, Postulations, Predictions Watch now

Part 3

Daily Wrap-Ups with Dr Alasnag & Dr Al-Shaibi

4 sessions
Day 1 Highlights: New Guidelines, STEP-HFpEF, COP-AF Watch now
Day 2 Highlights: BUDAPEST-CRT, FIRE, ECLS-Shock, STOPDAPT-3 Watch now
Day 3 Highlights: OCT Trials, MULTISTARS-AMI, ATTRibute-CM Watch now
Day 4 Highlights: OPT-BIRISK & NITRATE-CIN Watch now

Part 4

Expert Interviews

25 sessions
New Guidelines For the Management of Acute Coronary Syndromes Watch now
NOAH-AFNET 6: Oral Anticoagulation in Pts With AHRE Watch now
LODESTAR: Rosuvastatin Vs Atorvastatin Treatment For CAD Patients Watch now
Economic Burden of Cardiovascular Disease in the EU Watch now
OCEAN(a)-DOSE: Olpasiran in Patients with Atherosclerotic CVD and Elevated LP(a) Watch now
STOPDAPT-3: Prasugrel Monotherapy Without Aspirin in Acute Coronary Syndrome Patients Watch now
HEART-FID: Ferric Carboxymaltose in HF with Iron Deficiency Watch now
SurHyb Trial: Hybrid Ablation in Persistent Atrial Fibrillation Watch now
COMPARE-CRYO: PolarX Vs Arctic Front Cryoballoons for PVI in Pts With Paroxysmal AF Watch now
ILUMIEN IV: OCT Vs Angiography Watch now
ReDS-SAFE HF: ReDS-Guided Strategy in Heart Failure Watch now
MULTISTARS AMI: Immediate Vs Staged PCI in STEMI and MVD Watch now
OCT Vs IVUS Vs Angiography Guidance Watch now
OCTOBER: OCT-Guided or Angiography-Guided PCI in Complex Bifurcation Lesions Watch now
DANPACE II: Reducing Atrial Pacing in Sinus Node Disease Watch now
COP-AF: Colchicine for Perioperative AF Watch now
CASTLE-HTx: Catheter Ablation for AF in Pts with Heart Failure Watch now
OCTIVUS: OCT Vs IVUS-Guided Percutaneous Coronary Intervention Watch now
PUSH-AHF: Natriuresis-Guided Therapy in Acute Heart Failure Watch now
LIBerate-HeFH: Novel PCSK9-Inhibitor in Heterozygous Familial Hypercholesterolemia Watch now
ONCO DVT: Optimal Duration of DOAC Therapy for IDDVT Patients with Cancer Watch now
ATTRibute-CM Trial Watch now
RIGHT: Post-PPCI Anticoagulation in STEMI Patients Watch now
ARAMIS: Anakinra versus Placebo in Acute Myocarditis Watch now
FRAIL-AF: Non-Vitamin K Antagonist Anticoagulation in Frail Elderly Patients With AF Watch now

Part 5

Women as One & Radcliffe Cardiology Presents

2 sessions
Takeaways from ESC 2023 with Dr Cvijic & Dr Grapsa Watch now
Takeaways from ESC 2023 with Dr Al-Lamee, Dr Colleran & Dr Paradies Watch now

Part 6

Behind the Heart

23 sessions
Leadership in Guidelines and Cardiovascular Education with Dr Robert Byrne Watch now
Patient Care and Treatment Strategies with Dr Myeong-Ki Hong Watch now
Challenges and Opportunities in Investigator-Initiated Trials with Dr Paulus Kirchhof Watch now
Intersection of Politics and Medicine with Dr Luengo-Fernandez Watch now
Choosing Cardiology and Advice to Researchers with Dr Robert Mentz Watch now
Leadership in the Context of Clinical Trials with Dr Michelle O'Donoghue Watch now
Trials to Watch Out For with Dr Masahiro Natsuaki Watch now
Introducing Insights from New Data Into Clinical Practice with Dr Alan Bulava Watch now
Emerging Topics in Electrophysiology with Dr Tobias Reichlin Watch now
Key Trials and Data from ESC 23 with Dr Ziad Ali Watch now
Maintaining a Balance of Clinical Skills and New Data with Dr Jesus Alvarez-Garcia Watch now
Inspiring Teams with Prof Barbara Stahli Watch now
Advice for Early-Career Researchers from Dr Gregg Stone Watch now
New Technologies in Electrophysiology with Dr Mads Brix Kronborg Watch now
Considering Unmet Needs in Patient Care with Dr Duk-Woo Park Watch now
Improving Clinical Practice with Dr Do-Yoon Kang Watch now
Contributing to the Guidelines with Dr Jozine Ter Maaten Watch now
Emerging Trends in Amyloidosis with Prof Julian Gillmore Watch now
Working With Role Models with Dr Yan Yan Watch now
The Importance of Mentorship with Dr Giles Montalescot Watch now
Personalised Medicine & Team Approach With Dr Christian Sohns Watch now
Advancement of EP & Adapting New Approaches With Dr Philipp Sommer Watch now
Familial Hypercholesterolemia: Early Detection & Hope for Future Care With Dr Frederick Raal Watch now

About the episode

ESC 23 — Dr Michelle O'Donoghue (Brigham and Women's Hospital, US) outlines a trial update from OCEAN(a)-Dose (NCT05581303) in this succinct interview.

 

OCEAN(a)-DOSE (Amgen) was a dose-finding study aiming to evaluate a siRNA, olpasiran, and its effect on risk for coronary heart disease death, myocardial infarction or urgent coronary revascularization when administered subcutaneously as compared to placebo in patients with atherosclerotic cardiovascular disease and elevated Lipoprotein(a). 

 

In results revealed at AHA 2022, the trial showed that when dosed at 75mg or higher every 12 weeks, olpasiran reduced Lp(a) concentration by more than 95% in patients with atherosclerotic cardiovascular disease, and the treatment to be safe and well-tolerated.

 

This trial update from ESC 2023 investigated an off-treatment period in the same patient group. This late-breaking update revealed that patients treated with a higher dose of olpasiran had a 40-50% reduction in LP(a) up to a year after their last dose.

 

Questions:

  1. What do we know about the role of Lp(a)? What are the available treatments for addressing Lp(a) concentrations?
  2. What question does this extension study aim to address?
  3. What was the study design and eligibility criteria?
  4. What are the key findings presented at ESC?
  5. What are the take-home messages?
  6. What are the remaining questions? What are the next steps?

 

Recorded on-site at ESC Congress 2023, Amsterdam.

 

Editors: Mirjam Boros and Jordan Rance

Video Specialists: Dan Brent, Tom Green, Mike Knight, Oliver Miles

Faculty Biographies

Michelle O'Donoghue

Michelle O'Donoghue

Associate Physician

Dr Michelle O’Donoghue, is an Associate Physician in the Cardiology Division of Brigham and Women’s Hospital, an Affiliate Physician in the Cardiology Division of Massachusetts General Hospital and an Assistant Professor in Medicine at Harvard Medical School in Boston, Massachusetts, US.  She is an investigator in the Thrombolysis in Myocardial Infarction (TIMI) Study Group, founded by Dr Eugene Braunwald. 

Dr O’Donoghue’s primary research focus is the design and conduct of multicentre clinical trials for patients with stable and unstable heart disease.  Additional clinical research interests include the evaluation of novel antiplatelet drugs, established and novel biomarkers, the study of women and heart disease and the development of novel therapeutics in the management of acute coronary syndromes.

View full profile

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