ESC 23: Hot Line & Late-breaking Science Video Collection

Published: 04 August 2023

  • Views:

    Views Icon 4583
  • Likes:

    Heart Icon 7
Average (ratings)
No ratings
Your rating

Overview

What's hot at the European Society of Cardiology (ESC) Congress 2023?

Browse our curated coverage of the latest updates in cardiology from Amsterdam.

  • Watch our View From the Thoraxcenter series for a concise line up of the most awaited trials from Prof Nicolas Van Mieghem and Dr Joost Daemen
  • For a deeper dive into key clinical trial data and its applicability, host, Dr Harriette Van Spall meets with Principal Investigators in her Late-Breaker Discussion series.
  • View a condensed summary of the crucial takeaways from each day in our Wrap-Up series with Dr Mirvat Alasnag.
  • Our short, accessible Expert Interviews with select faculty focus on data, patient care and the future of their field.
  • We will feature personal perspective in Behind the Heart series focusing on career pathways, personal motivations and perspectives on the field.

More from this programme

Part 4

Expert Interviews

25 sessions
New Guidelines For the Management of Acute Coronary Syndromes Watch now
NOAH-AFNET 6: Oral Anticoagulation in Pts With AHRE Watch now
LODESTAR: Rosuvastatin Vs Atorvastatin Treatment For CAD Patients Watch now
Economic Burden of Cardiovascular Disease in the EU Watch now
OCEAN(a)-DOSE: Olpasiran in Patients with Atherosclerotic CVD and Elevated LP(a) Watch now
STOPDAPT-3: Prasugrel Monotherapy Without Aspirin in Acute Coronary Syndrome Patients Watch now
HEART-FID: Ferric Carboxymaltose in HF with Iron Deficiency Watch now
SurHyb Trial: Hybrid Ablation in Persistent Atrial Fibrillation Watch now
COMPARE-CRYO: PolarX Vs Arctic Front Cryoballoons for PVI in Pts With Paroxysmal AF Watch now
ILUMIEN IV: OCT Vs Angiography Watch now
ReDS-SAFE HF: ReDS-Guided Strategy in Heart Failure Watch now
MULTISTARS AMI: Immediate Vs Staged PCI in STEMI and MVD Watch now
OCT Vs IVUS Vs Angiography Guidance Watch now
OCTOBER: OCT-Guided or Angiography-Guided PCI in Complex Bifurcation Lesions Watch now
DANPACE II: Reducing Atrial Pacing in Sinus Node Disease Watch now
COP-AF: Colchicine for Perioperative AF Watch now
CASTLE-HTx: Catheter Ablation for AF in Pts with Heart Failure Watch now
OCTIVUS: OCT Vs IVUS-Guided Percutaneous Coronary Intervention Watch now
PUSH-AHF: Natriuresis-Guided Therapy in Acute Heart Failure Watch now
LIBerate-HeFH: Novel PCSK9-Inhibitor in Heterozygous Familial Hypercholesterolemia Watch now
ONCO DVT: Optimal Duration of DOAC Therapy for IDDVT Patients with Cancer Watch now
ATTRibute-CM Trial Watch now
RIGHT: Post-PPCI Anticoagulation in STEMI Patients Watch now
ARAMIS: Anakinra versus Placebo in Acute Myocarditis Watch now
FRAIL-AF: Non-Vitamin K Antagonist Anticoagulation in Frail Elderly Patients With AF Watch now

Part 6

Behind the Heart

23 sessions
Leadership in Guidelines and Cardiovascular Education with Dr Robert Byrne Watch now
Patient Care and Treatment Strategies with Dr Myeong-Ki Hong Watch now
Challenges and Opportunities in Investigator-Initiated Trials with Dr Paulus Kirchhof Watch now
Intersection of Politics and Medicine with Dr Luengo-Fernandez Watch now
Choosing Cardiology and Advice to Researchers with Dr Robert Mentz Watch now
Leadership in the Context of Clinical Trials with Dr Michelle O'Donoghue Watch now
Trials to Watch Out For with Dr Masahiro Natsuaki Watch now
Introducing Insights from New Data Into Clinical Practice with Dr Alan Bulava Watch now
Emerging Topics in Electrophysiology with Dr Tobias Reichlin Watch now
Key Trials and Data from ESC 23 with Dr Ziad Ali Watch now
Maintaining a Balance of Clinical Skills and New Data with Dr Jesus Alvarez-Garcia Watch now
Inspiring Teams with Prof Barbara Stahli Watch now
Advice for Early-Career Researchers from Dr Gregg Stone Watch now
New Technologies in Electrophysiology with Dr Mads Brix Kronborg Watch now
Considering Unmet Needs in Patient Care with Dr Duk-Woo Park Watch now
Improving Clinical Practice with Dr Do-Yoon Kang Watch now
Contributing to the Guidelines with Dr Jozine Ter Maaten Watch now
Emerging Trends in Amyloidosis with Prof Julian Gillmore Watch now
Working With Role Models with Dr Yan Yan Watch now
The Importance of Mentorship with Dr Giles Montalescot Watch now
Personalised Medicine & Team Approach With Dr Christian Sohns Watch now
Advancement of EP & Adapting New Approaches With Dr Philipp Sommer Watch now
Familial Hypercholesterolemia: Early Detection & Hope for Future Care With Dr Frederick Raal Watch now

About the episode

ESC 23 - Late-Breaker host, Dr Harriette Van Spall (McMaster University, CA) is joined by Dr Mikhail Kosiborod (Saint Luke’s Mid America Heart Institute, US) to discuss the findings from the STEP HFpEF trial.

 

Around half of patients with heart failure have heart failure with preserved ejection fraction (HFpEF), and most patients with HFpEF are overweight or obese. Patients with obesity-related HFpEF have a high burden of debilitating symptoms and physical limitations, leading to a poor quality of life. 

 

Semaglutide is a GLP-1 receptor antagonist, which has been shown to substantially produce weight loss in people who are overweight and obese. STEP HFpEF aimed to test the hypothesis that treatment with semaglutide can improve symptoms in patients with HFpEF and obesity. 592 patients were randomized to receive once-weekly semaglutide 2.4mg or placebo for 1 year. 

 

The trial met both primary endpoints, showing a mean change in body weight of -13.3% with semaglutide, and a change in KCCQ-CCS of 16.6 points from baseline to week 52.


 
Recorded on-site at ESC Congress 2023, Amsterdam. 

 

Editors: Mirjam Boros and Jordan Rance

Video Specialists: Dan Brent, Tom Green, Mike Knight, Oliver Miles

Faculty Biographies

Harriette Van Spall

Harriette Van Spall

Associate Professor of Medicine, Director of E-Health and Virtual Care

Dr Harriette Van Spall is an Associate Professor of Medicine and cardiologist and serves as Director of E-Health at McMaster University, Canada. She completed her medical and postgraduate clinical training at the University of Toronto and earned a Master of Public Health degree at Harvard University, US. Dr Van Spall is a Canadian Institutes of Health Research-funded clinical trialist and researcher with a focus on heart failure, health services, and health disparities.

She has garnered more than $4 million in research funding, has won several research awards, and has published her work in high-impact medical journals. She is an invited speaker, media correspondent, and editorial board member active in peer review at several high-impact medications journals and grant funding agencies, including Canadian Institutes of Health Research and Heart and Stroke Foundation of Canada.

Dr Van Spall is an Editorial Board…

View full profile
Mikhail Kosiborod

Mikhail Kosiborod

Cardiologist

Dr Mikhail Kosiborod is a cardiologist, the Vice President of Research at Saint Luke's Health System, and Professor of Medicine at the University of Missouri-Kansas City, US.

He is also Director of Cardiometabolic Research and Co-Director of the Saint Luke’s Michael & Marlys Haverty Cardiometabolic Center of Excellence at Saint Luke's Mid America Heart Institute. Dr Kosiborod is an internationally-recognised expert in the fields of diabetes and cardiovascular disease, cardiometabolic and cardiorenal syndromes.

Dr Kosiborod is involved in the leadership of numerous clinical trials and multi-center registries, and is currently the principal investigator of several investigator-initiated, multi-center trials in diabetes and cardiovascular disease.

View full profile

Comments

You must be to comment. If you are not registered, you can register here.