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Statins and Insulin Resistance
Author(s): GM Sanvee , M Panajatovic , J Bouitbir , et al Added: 3 years ago
Statins are lipid-lowering drugs that are beneficial for the cardiovascular system. However, they are associated with skeletal muscle disorders and, recently, with insulin resistance and new-onset diabetes. To date, mechanisms underlying statin-induced insulin resistance are not fully elucidated. The goals of the study were to characterise effects of simvastatin on glucose metabolism and… View more

Prevention & Chronic Conditions
Statins: Practical Considerations – A Review
Author(s): Kazeen Abdullah , Anand Rohatgi Added: 3 years ago
Statins are currently the most efficacious and widely prescribed lipid-lowering medications.1 Numerous randomised controlled trials across a spectrum of baseline atherosclerotic cardiovascular disease (ASCVD) risk show that a 1.0 mmol/L (~40 mg/dL) reduction in low-density lipoprotein cholesterol (LDL-C) with statin therapy is associated with an overall 21 % reduction in major vascular events and… View more

Standards & Guidelines

Prevention & Chronic Conditions
Author(s): Laurent Fauchier Added: 3 years ago
Hypothetically, 3-hydroxy-3-methylglutaryl co-enzyme A (HMG-CoA) reductase inhibitors (statins) protect against arrhythmias in addition to their well-established secondary prevention benefits against atherosclerotic coronary artery disease. The use of statins has been suggested to protect against atrial fibrillation (AF) in some clinical studies, but remains rather inadequately explored… View more

Electrophysiology & Arrhythmia
ACC 23: Statins to Protect Heart During Cancer Treatment: The STOP-CA Trial
Author(s): Marielle Scherrer-Crosbie Added: 1 year ago
ACC.23/WCC — In this succinct late-breaking science interview, Investigator, Dr Marielle Scherrer-Crosbie (Hospital of the University of Pennsylvania, US) discusses the results from the STOP-CA trial (Massachusetts General Hospital). This randomized phase II trial aims to investigate whether atorvastatin, a commonly prescribed statin drug for reducing cholesterol levels, can protect the heart… View more

Heart Failure

Prevention & Chronic Conditions
The Effect of Statins on the Functionality
Author(s): Nilofer Sorathia , Hussein Al-Rubaye , Benham Zal Added: 3 years ago
Statins are most frequently prescribed for the primary prevention of cardiovascular disease due to their lipid-lowering properties. They are known to exert their effect by competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. The reduction in the synthesis of cholesterol induces upregulation of LDL receptors in the liver, resulting in increased clearance and… View more

Anticoagulation

Prevention & Chronic Conditions
Author(s): Marek Roik , Malgorzata H Starczewska , Grzegorz Opolski Added: 3 years ago
Diastolic heart failure (DHF) has become one of the largest problems facing us. The results of the Euro Heart Failure Survey showed that almost 50% of patients with clinical symptoms of chronic heart failure (CHF) have preserved left ventricular ejection fraction (LVEF).1 According to the recommendations of the European Society of Cardiology, DHF should be diagnosed only when signs or symptoms of… View more

Heart Failure

Prevention & Chronic Conditions
Author(s): Michel Farnier , John JP Kastelein Added: 3 years ago
Clinical trial evidence from the past two decades has demonstrated that lowering cholesterol levels markedly impacts the occurrence of cardiovascular (CV) disease, including coronary heart disease, a leading cause of mortality and morbidity in the US and Europe.1–7 Data from these studies form the basis of national and international treatment guidelines delineating lipid thresholds and… View more

Prevention & Chronic Conditions
Author(s): Renata Cífková Added: 3 years ago
Hypertension is the most prevalent cardiovascular disease affecting 20–50 % of the adult population.1 Elevated blood pressure has been identified as a risk factor for coronary heart disease (CHD), heart failure, stroke, peripheral arterial disease, renal failure and atrial fibrillation both in men and women in a large number of epidemiological studies.2–4 So far, the largest meta-analysis of… View more

Anticoagulation

Prevention & Chronic Conditions
AHA 23: SUPER LIPID
Author(s): Alexander Fanaroff Added: 5 months ago
AHA 2023 — We are joined by Dr Alexander Fanaroff (Penn Medicine, US) to discuss the findings from a cluster randomised trial of automated referral to centralised pharmacy services for evidence-based statin initiation in high-risk patients.Gaps have been observed in evidence-based statin prescriptions, where more than 50% of US adults with an indication for atherosclerotic cardiovascular disease… View more

Prevention & Chronic Conditions
Author(s): Claudio Borghi , Arrigo FG Cicero Added: 3 years ago
It is well known that hypertension is a strong independent risk factor for coronary and cerebrovascular diseases, as well as for heart failure, atrial fibrillation and chronic renal failure, in both industrialised and developing countries,1 thus substantially contributing to the global burden of disease. Moreover, it is well known that reducing blood pressure (BP) in hypertensive patients is… View more

Prevention & Chronic Conditions