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Author(s): Gustav Steinhoff Added: 3 years ago
Cell therapy for myocardial regeneration is an exciting new field of medical research that has the potential to revolutionise cardiovascular medicine. Despite significant improvements in emergency treatment, myocardial infarction (MI) leads to a net loss of contractile tissue in many patients with coronary artery disease (CAD). Often, this is the beginning of a downward spiral towards congestive… View more

Vascular Disease and Surgery

MI/ACS
Author(s): Daniel Alejandro Lerman , Nasri Alotti , Kiddy Levente Ume , et al Added: 3 years ago
Acute myocardial infarction (AMI) is still a major public health problem worldwide, causing high rates of morbidity and mortality. In the United States, nearly one million patients suffer from AMI each year.1 In the UK, around 80,000 people died from coronary heart disease (CHD) in 2010.2 The current approach to the treatment of myocardial infarction involves early revascularisation with… View more

Vascular Disease and Surgery

Heart Failure
Author(s): Hans-Michael Klein Added: 3 years ago
An increasing number of patients survive acute myocardial infarction. Surgical and interventional revascularisation of the ischaemic myocardium can treat angina, reduce risk of myocardial infarction and improve the function of the viable myocardium. However, the therapeutic possibilities in end-stage heart failure patients are limited. This article investigates alternative treatment options such… View more

Vascular Disease and Surgery

Heart Failure
Author(s): Gustav Steinhoff Added: 3 years ago
Cell therapy for myocardial regeneration is an exciting new field of medical research that has the potential to revolutionize cardiovascular medicine. Despite significant improvements in emergency treatment, myocardial infarction leads to a net loss of contractile tissue in many patients with coronary artery disease. Often, this is the beginning of a downward spiral towards congestive heart… View more

Vascular Disease and Surgery
Statins and Insulin Resistance
Author(s): GM Sanvee , M Panajatovic , J Bouitbir , et al Added: 3 years ago
Statins are lipid-lowering drugs that are beneficial for the cardiovascular system. However, they are associated with skeletal muscle disorders and, recently, with insulin resistance and new-onset diabetes. To date, mechanisms underlying statin-induced insulin resistance are not fully elucidated. The goals of the study were to characterise effects of simvastatin on glucose metabolism and… View more

Prevention & Chronic Conditions
HDL Mimetics Enhances Mitochondrial Function via Stimulation of PGC1-α
Author(s): Hang Zhang , Tomohiro Komatsu , Shihoko Nakashima , et al Added: 11 months ago

Prevention & Chronic Conditions
Job title: Cardiologist
Prof Wolfram Doehner is aCardiologist andProfessor of Interdisciplinary Stroke Research atCharité – Universitätsmedizin Berlin, Berlin, DE. He was a member of the ESC programme committee (2014-2020) and was Chairman (2018-2020) of the ESC Council on Stroke. ProfDoehner's research focus is the peripheral aspect, and particularly, the skeletal muscle structure and metabolism in stroke… View more
Role of PGC-1-alpha-associated Mitochondrial Biogenesis in Statin-induced Myotoxicity
Author(s): M Panajatovic , F Singh , U Duthaler , et al Added: 3 years ago
Aim: Statins are well tolerated but can be associated with mitochondrial dysfunction in skeletal muscles. Statins impair mitochondrial proliferation by decreasing PGC-1α expression in human and rat skeletal muscle, suggesting a role of PGC-1α in statin-induced myotoxicity. This study aimed to investigate these effects in differentially expressed PGC-1α mouse models. Methods: We used three mouse… View more

Prevention & Chronic Conditions
Alicia Morgans
Research Area(s) / Expertise:

Cardio-oncology

 Job title: Medical Director, Survivorship Program
A Genitourinary Medical Oncologist at the Dana-Farber Cancer Institute, Alicia Morgans serves as the Medical Director of the Survivorship Program. She is an experienced clinician and researcher with knowledge of patient-reported outcomes, clinical trials, and incorporating patient preferences and beliefs into therapeutic decision-making. Her studies have looked into the skeletal, cardiovascular,… View more
Author(s): Gurushankar Govindarajan , James R Sowers , Craig S Stump Added: 3 years ago
There has been an increase in the prevalence of diabetes mellitus over the past 40 years, both in the US and worldwide. The worldwide prevalence of diabetes in 2000 was approximately 2.8% and is estimated to grow to 4.4% by 2030. This translates to a projected rise of diabetes from 171 million in 2000 to well over 350 million in 2030. The epidemic of diabetes will continue to rise as there is… View more

Prevention & Chronic Conditions