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Added:
3 years ago
Why Do We Need Risk Stratification Tools?
Sudden death accounts for between 300,000 and 500,000 deaths each year in North America.1 Patients with a history of myocardial infarction (MI) have a four-fold higher risk of sudden death than those without such a history. Most sudden deaths in ambulatory populations result from life-threatening ventricular arrhythmias that lead to a cardiac arrest.2…
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3 years ago
Introduction
The Brugada syndrome (BrS) is a hereditary arrhythmia syndrome manifesting as recurrent syncope or sudden cardiac death (SCD) due to polymorphic ventricular (VT) or fibrillation (VF) in the absence of overt structural heart disease or myocardial ischaemia.1,2 The prevalence of the syndrome is estimated at around 15 per 10,000 in South East Asia including Japan and around 2 per 10,000…
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3 years ago
Sudden cardiac death (SCD) can be defined as unexpected death that occurs within one hour of the onset of symptoms or during sleep in a person who was previously stable. The mode of death, which may be due to an arrhythmic or non-arrhythmic cause, depends on the underlying cardiovascular abnormality (mechanical or electrical substrate). SCD remains a major public health problem worldwide and is…
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3 years ago
Brugada syndrome (BrS) is an inherited disease with an increased risk of sudden cardiac death (SCD). Despite the wide spectrum of clinical manifestations, young and apparently healthy individuals are the most frequently affected by this devastating event.1,2 During the last 20 years, the genetic basis of Brugada syndrome has been extensively investigated, leading to major changes in gene encoding…
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3 years ago
Sudden cardiac arrest (SCA) can be defined as the abrupt cessation of cardiac activity due to an underlying cardiac cause, occurring instantaneously in a previously stable patient and in the absence of non-cardiovascular causes (e.g., trauma, intoxication, drowning, electrocution).1,2 SCA will lead to loss of consciousness within the minute due to insufficient cerebral perfusion. If no immediate…
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3 years ago
Ischaemic heart disease is the leading single cause of death in the US and elsewhere, and a major health problem worldwide.1 The direct cost of hospitalisations for ischaemic heart disease in the US alone is enormous and amounts to more than US$15 billion. Consequently, it is very important to facilitate more definitive ischaemia evaluation while avoiding unnecessary hospital admissions of non…
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Added:
3 years ago
Ischaemic heart disease is the leading single cause of death in the US and elsewhere, and a major health problem worldwide.1 The direct cost of hospitalisations for ischaemic heart disease in the US alone is enormous and amounts to more than US$15 billion. Consequently, it is very important to facilitate more definitive ischaemia evaluation while avoiding unnecessary hospital admissions of non…
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Added:
3 years ago
Myocardial infarction (MI) is associated with acute risk of early malignant arrhythmias that can be easily treated during in-hospital intensive care by defibrillation, adjuvant antiarrhythmic therapy or even catheter ablation in resistant cases. Indeed, such management resulted in substantial improvement in MI survival rate. Despite the implementation of primary percutaneous coronary…
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3 years ago
Left ventricular (LV) systolic dysfunction, defined by depressed LV ejection fraction (LVEF), has been recognised over the last two decades as the most robust parameter for identifying risk of sudden cardiac death (SCD). Specifically, LVEF has been a major determinant for entry into numerous randomised trials that aimed to investigate the efficacy of implantable cardioverter–defibrillators (ICDs)…
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Added:
2 years ago
