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Author(s): Hiroshi Watanabe Added: 3 years ago
Pulmonary arterial hypertension (PAH) is a chronic and life-threatening disease characterised by progressive vascular remodelling that leads to increased pulmonary vascular resistance, right ventricular heart failure and death. PAH is defined by >25 mmHg increase in pulmonary arterial blood pressure and a pulmonary capillary wedge pressure of 15 mmHg.1 If left untreated PAH is fatal; it has a… View more

Prevention & Chronic Conditions
Author(s): Markus Flesch Added: 3 years ago
Introduction Chronic heart failure (HF) is a common, malignant disease and is a major economic burden for healthcare systems in developed nations. It affects 5% to 10% of all people. In Germany, approximately 150,000 people are newly diagnosed with HF per year. Fifteen per cent of approximately 1.6 million HF patients in Germany are in advanced HF status, being classified as stage III-IV… View more

Heart Failure
Author(s): Christopher S Hayward , Marc Swartz Added: 3 years ago
Heart failure is an escalating global pandemic and one of the leading causes of death and disability in the developed world. At present, the incidence of heart failure in the Western world is staggering, affecting approximately 6.5 million people in Europe and 5.8 million people in the US.1–3 Even more alarming is the notion that approximately 10 % of this population suffers from advanced heart… View more

Imaging & Diagnostics

Heart Failure
Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype?
Author(s): Alexandros Protonotarios , Perry Elliott Added: 3 years ago
Until the 20th century, conventional medicine relied almost exclusively on observable characteristics to classify and treat human disease.1 Even in the modern era, physicians define diseases using phenotypic similarities and employ relatively simple algorithms to interpret diagnostic tools and plan treatment. The advent of low-cost genetic sequencing and its introduction into clinical care… View more

Heart Failure
Chagas Disease and Heart Failure
Author(s): Felipe Martínez , Eduardo Perna , Sergio V Perrone , et al Added: 3 years ago
Chagas disease was initially described as an endemic health problem in a few countries in South America – mainly Argentina and Brazil – and one of the consequences of the disease, heart damage, made it an interesting issue for healthcare professionals, from epidemiologists to cardiologists.1 Chagas cardiomyopathy (ChCM) is now recognised as a cardiovascular disorder, diagnosed and treated not… View more

Heart Failure
Author(s): Mauro Pepi , Adam Staron , Gloria Tamborini Added: 3 years ago
Progress in 3D echocardiography was slow in the 1980s and 1990s, due mainly to technical reasons. Recently, along with the rapid evolution in probe and computer technologies, 3D echocardiography has grown into a well-developed technique that is able to display images of the heart that contain important new tissue and morphological information. This new technique is simple and rapid and enables… View more

Imaging & Diagnostics
Author(s): Akihiko Nogami Added: 3 years ago
No apparent structural abnormality is identified in approximately 10% of all sustained monomorphic ventricular tachycardias (VTs) in the US1 and in 20% of those in Japan.2 These VTs are referred to as ‘idiopathic’. Idiopathic VTs usually occur in specific locations and have specific QRS morphologies, whereas VTs associated with structural heart disease have a QRS morphology that tends to indicate… View more

Electrophysiology & Arrhythmia
Author(s): Gianfranco Sinagra , Michele Moretti , Giancarlo Vitrella , et al Added: 3 years ago
According to the latest position statement of the European Society of Cardiology (ESC), cardiomyopathies (CMP) are defined as “myocardial disorders in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disease sufficient to cause the observed myocardial abnormality”.1 CMP may be… View more

Imaging & Diagnostics

Heart Failure
Author(s): Lee Chang , Robert Yeh Added: 3 years ago
Cardiogenic shock is the leading cause of death in patients with acute ST-elevation myocardial infarction (STEMI). Characterised by a state of low cardiac output leading to end-organ hypoperfusion, cardiogenic shock complicates approximately 5–8 % of STEMIs and is associated with a mortality rate approaching 50 percent.1–3 Prompt recognition and therapeutic intervention for cardiogenic shock due… View more

Vascular Disease and Surgery

Prevention & Chronic Conditions
Author(s): Sitaramesh Emani , William T Abraham Added: 3 years ago
Heart failure (HF) is a growing epidemiological challenge in the US and worldwide. In the US, it is estimated that at least 5 million people are affected by it, with more than a half-million new diagnosis being made each year.1 Despite major improvements in the treatment of HF, almost 30 % of patients treated for acute HF require readmission within 30 days.2,3 These sobering statistics underscore… View more

Heart Failure

Prevention & Chronic Conditions