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Author(s): Laurent Bonello Added: 3 years ago
Clopidogrel is a key antiplatelet agent that inhibits the second step of platelet aggregation through blockade of the P2Y12-adenosine diphosphate (ADP) receptor.1 Its use has enabled percutaneous coronary intervention (PCI) to expand by dramatically reducing thrombotic complications in acute coronary syndromes (ACSs).2,3 Since the first report by Jaremo et al. of a large inter-individual… View more

Anticoagulation

MI/ACS
Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype?
Author(s): Alexandros Protonotarios , Perry Elliott Added: 3 years ago
Until the 20th century, conventional medicine relied almost exclusively on observable characteristics to classify and treat human disease.1 Even in the modern era, physicians define diseases using phenotypic similarities and employ relatively simple algorithms to interpret diagnostic tools and plan treatment. The advent of low-cost genetic sequencing and its introduction into clinical care… View more

Heart Failure
Simvastatin is Independently Improving Uremic Cardiomyopathy Through Intercommunication Between Macrophage and Cardiomyocyte in Renal Failure Model
Author(s): Barinda Agian Jeffilano , Wawaimuli Arozal , Ulfa Tri Wahyuni , et al Added: 2 years ago

Prevention & Chronic Conditions
Author(s): Josep Lupón , Antoni Bayés-Genís Added: 3 years ago
The left ventricular ejection fraction (LVEF) – calculated as the stroke volume (end-diastolic volume minus end-systolic volume) divided by the end-diastolic volume – remains the main driver for categorising heart failure (HF) and it is a cornerstone in all randomised clinical trials for patients with HF. Although LVEF has many acknowledged limitations, it remains key for the classification,… View more

Heart Failure
Michael Fu
Job title: Professor, Principal Investigator, Senior Consultant Physician/Cardiologist
Professor Michael Fu is currently a nucleus member of working group of heart failure with preserved ejection fraction, Heart Failure Association, European Society of Cardiology, and an nucleus member of the National Working Group of Heart Failure in Sweden. Michael Fu is an expert in heart failure with research focus on epidemiology, clinical phenotype, prognosis and its risk factors,… View more
HF 2022: Heart Failure Highlights of 2022 with Prof Cleland
Author(s): John GF Cleland Added: 1 year ago
Prof John Cleland (University of Glasgow & Glasgow Royal Infirmary, Glasgow, UK) joined us to talk about heart failure management highlights in 2022 including a new phenotype, HFsnEF; available and new treatment options; news on SGLT2is and more. Recorded at Heart Failure 2022, Madrid. Videographer: Tom Green Editor: Mirjam Boros View more

Standards & Guidelines

Heart Failure
AHA 21: EAST-AFNET 4: Early Rhythm Control was Consistent in AF Patterns
Author(s): Andreas Goette Added: 2 years ago
In this short video interview, Prof Andreas Goette (St Vincenz Hospital Paderborn, Paderborn, DE) discusses the findings from the the EAST-AFNET 4 Trial. The trial investigated whether rhythm control therapy delivered within one year after AF diagnosis improves outcomes. The trial, presented at AHA 21, demonstrated that clinical benefit of early rhythm control was consistent in AF patterns. … View more

Electrophysiology & Arrhythmia
Applications for Induced Pluripotent Stem Cells in Disease Modelling and Drug Development for Heart Diseases
Author(s): Shu Nakao , Dai Ihara , Koji Hasegawa , et al Added: 3 years ago
Induced Pluripotent Stem Cells and Their Potential Applications Induced pluripotent stem cells (iPSCs) are generated from somatic cells, such as skin fibroblasts, by ectopic expression of defined reprogramming factors. Within a few years of the first report of the generation of mouse iPSCs, several laboratories reportedly reproduced these cells using other cell types and species using similar… View more

Vascular Disease and Surgery
Author(s): Keith AA Fox Added: 3 years ago
Cardiology was never forefront on my mind. I grew up in Central Africa in Zimbabwe where my father was a banker and I went to local schools. I always had an interest in the sciences so during a gap year between school and university I worked in the Queen Elizabeth Hospital in Malawi in the labs and trauma outpatient clinic. This fed my enthusiasm to pursue science and was really quite informative… View more

Prevention & Chronic Conditions
Hypertrophic Cardiomyopathy in Athletes
Author(s): Aneil Malhotra , Sanjay Sharma Added: 3 years ago
Athletes who perform regular and intensive exercise regimes develop a variety of electrical and structural cardiac adaptations that manifest functionally to improve stroke volume and performance. Up to one-fifth of young athletes (aged between 14–35 years) reveal greater left ventricular (LV) wall thickness compared to sedentary controls, though the majority fall under 12 mm.1,2 A small… View more

Heart Failure