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Author(s): Roland E Schmieder Added: 3 years ago
It is widely acknowledged that effective management of hypertension – even if blood pressure (BP) is reduced by only 2mmHg – can significantly reduce the incidence of stroke, myocardial infarction (MI) and heart failure (HF).1 However, despite the wide range of conventional antihypertensive agents available, approximately 70% of patients fail to achieve adequate BP control.2 Furthermore, although… View more

Prevention & Chronic Conditions
View from the Thoraxcenter: TCT 23 Late-breaking Science Preview
Author(s): Joost Daemen , Nicolas M Van Mieghem Added: 6 months ago
What's hot at TCT 2023? In this episode of View from the Thoraxcenter, Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcenter, Erasmus MC, NL) preview the late-breaking data presented at TCT 2023. With their dynamic analysis, these anticipated trials are placed in context, highlighting the real-world implications tied to the data releases. Top trials covered: 00:31 - 02:12: PARTNER 3 Low… View more

Intervention
Author(s): Ian G Burwash Added: 3 years ago
Aortic stenosis (AS) is a progressive disease of worsening left ventricular outflow obstruction. In the early stage of the disease, the prognosis is excellent with a very small risk of sudden death (<1 % per year).1–3 However, the development of a haemodynamically severe stenosis and the onset of symptoms herald a dramatic deterioration in prognosis. At this point, aortic valve replacement … View more

Imaging & Diagnostics

Prevention & Chronic Conditions
Author(s): Douglas Ewan Cannie , Mohammed Majid Akhtar , Perry Elliott Added: 3 years ago
Heart failure is a global health challenge, affecting 1–2% of the population and up to an estimated 64 million people worldwide.1,2 In the UK, just under 1 million people have heart failure, with approximately 350 new diagnoses each year per 100,000 population.3 The lifetime risk of developing heart failure at 55 years of age is 33% for men and 28% for women.4 The heart failure population is… View more

Heart Failure
Author(s): Alberico L Catapano Added: 3 years ago
Introduction Hypercholesterolaemia plays a key role in the development and progression of atherosclerosis and is a proven risk factor for coronary heart disease (CHD).1-4 Therapeutic interventions to lower cholesterol levels both in primary and secondary prevention trials show a clear reduction in the incidence of CHD and stroke.5-11 3-hydroxy-3-methylglutaryl co-enzyme A (HMG-CoA) reductase… View more

Heterogeneous Populations

Prevention & Chronic Conditions
Author(s): Alberico L Catapano Added: 3 years ago
Introduction Hypercholesterolaemia plays a key role in the development and progression of atherosclerosis and is a proven risk factor for coronary heart disease (CHD).1-4 Therapeutic interventions to lower cholesterol levels both in primary and secondary prevention trials show a clear reduction in the incidence of CHD and stroke.5-11 3-hydroxy-3-methylglutaryl co-enzyme A (HMG-CoA) reductase… View more

Prevention & Chronic Conditions
Author(s): Alberto Lorenzatti , Maria Luz Servato Added: 3 years ago
Coronary artery disease (CAD) is the leading cause of death in most countries. Compelling evidence from epidemiological, genetic and clinical studies as well as experiments in animal models has unquestionably established that elevated concentrations of cholesterol (mainly transported by LDL particles) promote atherosclerotic lesions.1 Although statin-based lipid-lowering therapies have been shown… View more

Prevention & Chronic Conditions
Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype?
Author(s): Alexandros Protonotarios , Perry Elliott Added: 3 years ago
Until the 20th century, conventional medicine relied almost exclusively on observable characteristics to classify and treat human disease.1 Even in the modern era, physicians define diseases using phenotypic similarities and employ relatively simple algorithms to interpret diagnostic tools and plan treatment. The advent of low-cost genetic sequencing and its introduction into clinical care… View more

Heart Failure
Author(s): Sitaramesh Emani , William T Abraham Added: 3 years ago
Heart failure (HF) is a growing epidemiological challenge in the US and worldwide. In the US, it is estimated that at least 5 million people are affected by it, with more than a half-million new diagnosis being made each year.1 Despite major improvements in the treatment of HF, almost 30 % of patients treated for acute HF require readmission within 30 days.2,3 These sobering statistics underscore… View more

Heart Failure

Prevention & Chronic Conditions
Author(s): Hug Cuéllar-Calàbria , Río Aguilar-Torres Added: 3 years ago
Cardiac computed tomography (CT) has become a useful non-invasive technique for the study of cardiac pathology in daily clinical practice due to its high negative predictive value for detecting coronary artery disease (CAD). Its established main role in clinical practice is ruling out CAD in symptomatic patients with intermediate risk of CAD, who remain a diagnostic problem after other non… View more

Imaging & Diagnostics

Prevention & Chronic Conditions