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The ACURATE IDE Post-Hoc Analysis
Author(s): Raj Makkar Added: 8 months ago
EuroPCR 25 - Post-hoc anlysis outcomes from under-expansion of the ACURATE neo2 valve in severe aortic stenosis (AS) patients show under-expansion was associated with higher rates of death, stroke or rehospitalisation.We are joined by Dr Raj Makkar (Cedars-Sinai Heart Institute, Los Angeles, US) to discuss findings from the post-hoc analysis of the ACURATE IDE study (NCT03735667; Boston… View more

Intervention

Vascular Disease and Surgery
Autophagy and Endoplasmic Reticulum Stress in HFpEF
Author(s): Citrawati Dyah Kencono Wungu , Hendri Susilo , Cleodylon Reinard Susanto , et al Added: 2 days ago

Heart Failure

MI/ACS
TCT 25: VICTORY Trial: Intravascular Lithotripsy vs Super-High-Pressure Balloons for Calcified Coronary Lesions
Author(s): Matthias Bossard Added: 3 months ago
TCT 2025 - The randomized VICTORY Study finds OCT-guided PCI involving lesion preparation with the OPN super-high-pressure non-compliant balloon is non-inferior to intravascular lithotropsy.Dr Matthias Bossard (Kantonsspital Lucerne, Lucerne, CH) joins us to discuss findings from the VICTORY Trial, a randomized, multicenter, non-inferiority comparison evaluating intravascular lithotripsy versus… View more

Intervention

MI/ACS
TCT 2025: Short-CUT: Lithotripsy Vs Cutting Balloon for CAD
Author(s): Suzanne J Baron Added: 3 months ago
TCT 2025 — Dr Suzanne J Baron (Massachusetts General Hospital, US), principal investigator of the Short-CUT trial (NCT06089135; Baim Institute for Clinical Research), joins us to discuss this investigator-initiated, multicentre randomized controlled study.The trial enrolled 410 patients with moderate to severe coronary artery calcification across up to 22 international sites. Eligible… View more

Intervention
Tirzepatide Benefits in HFpEF Consistent Across Obesity Levels, SUMMIT Analysis Shows
Added: 6 months ago Source:  Radcliffe CVRM
A secondary analysis of the SUMMIT trial has found that the benefits of tirzepatide on reducing the risk of cardiovascular death or worsening heart failure (HF) are consistent across all levels of obesity in patients with heart failure with preserved ejection fraction (HFpEF).¹ However, patients with a higher baseline body mass index (BMI) experienced greater improvements in exercise capacity and… View more

Cardiovascular Renal Metabolic

Heart Failure
Marina Vivarelli
Research Area(s) / Expertise:

Chronic Kidney Disease

 Job title: Laboratory of Nephrology, Bambino Gesù Children's Hospital, Rome, Italy
Dr. Marina Vivarelli is a renowned pediatric nephrologist with extensive expertise in immune-mediated renal diseases. Initially trained as a pediatrician, she developed a strong focus on pediatric immunology, working in the labs of leading experts like Fabrizio De Benedetti in Pavia and Raif Geha at Children's Hospital Boston. Since 2006, Dr. Vivarelli has been part of the Division of Nephrology… View more
The Coronary Microcirculation Re-explored
Author(s): Ahmed Elamin , Mustafa Abdimalik , Mohanad Abdelrahim , et al Added: 3 months ago

Prevention & Chronic Conditions
Semaglutide Modulates Key Pathways to Resolve MASH, Proteomic Analysis Reveals
Added: 6 months ago Source:  Radcliffe CVRM
A new study has explored the underlying mechanisms by which semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), improves outcomes in patients with metabolic dysfunction-associated steatohepatitis (MASH).¹ The research, which combined analysis of a phase 2 clinical trial with preclinical models, identified a unique proteomic signature associated with treatment and suggests that… View more

Cardiovascular Renal Metabolic
ACURATE neo2 Underexpansion Linked to Poorer Outcomes in ACURATE IDE Trial
Added: 6 months ago Source:  Radcliffe Cardiology
A post hoc analysis of the ACURATE IDE trial has found that underexpansion of the ACURATE neo2 transcatheter heart valve (THV) was associated with a higher rate of adverse clinical outcomes at one year.¹ The original trial failed to demonstrate non-inferiority of the ACURATE neo2 valve compared with contemporary commercial valves for the primary endpoint of all-cause mortality, stroke, or… View more

Imaging & Diagnostics

Intervention
Carla Nester
Research Area(s) / Expertise:

Chronic Kidney Disease

 Job title: Jean Robillard Professor of Pediatric Nephrology, Director of Pediatric Nephrology, Dialysis, and Transplantation, University of Iowa Stead Family Children’s Hospital, Iowa City, US
Dr. Carla M. Nester, MD, MSA, FASN, is the Jean Robillard Professor of Pediatric Nephrology and the Division Director of Pediatric Nephrology, Dialysis, and Transplantation at the University of Iowa Stead Family Children’s Hospital in Iowa City, IA. She is also the Associate Director of the Molecular Otolaryngology and Renal Research Laboratories (MORL) at the University of Iowa, the largest… View more