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Author(s): Alberto Lorenzatti , Maria Luz Servato Added: 3 years ago
Coronary artery disease (CAD) is the leading cause of death in most countries. Compelling evidence from epidemiological, genetic and clinical studies as well as experiments in animal models has unquestionably established that elevated concentrations of cholesterol (mainly transported by LDL particles) promote atherosclerotic lesions.1 Although statin-based lipid-lowering therapies have been shown… View more
Author(s): Sotirios Tsalamandris , Alexios S Antonopoulos , Evangelos Oikonomou , et al Added: 3 years ago
Diabetes is a multifaceted metabolic disorder affecting the glucose status of the human body. Impaired glucose tolerance and hyperglycaemia are the main clinical and diagnostic features and the result of an absolute or relative insulin deficiency or resistance to its action. Chronic hyperglycaemia associated with diabetes can result in end organ dysfunction and failure which can involve the… View more
Author(s): Robert P Frantz Added: 3 years ago
Pulmonary arterial hypertension (PAH) is a rare but life-threatening condition that has traditionally required treatment with continuous intravenous epoprostenol via an indwelling central catheter.1–3 Such therapy improves outcome, but is fraught with side effects, expense, and risk of catheter-related complications. Therapy of PAH has evolved tremendously in recent years, reflecting the… View more
Author(s): Sven M Francque Added: 3 years ago
Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease in western countries.1,2 It is closely associated with obesity, diabetes, dyslipidaemia and the metabolic syndrome, and shares common risk factors and pathophysiological mechanisms with these entities.2,3 NAFLD can be associated with hepatocellular damage and inflammation and is then called non-alcoholic… View more