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Author(s):
Harriette Van Spall
,
Mandeep Mehra
Added:
4 months ago
AHA 23 - Investigator, Dr Mandeep R Mehra (Brigham and Women's Hospital and Harvard Medical School, US) is joined by Late-breaker host, Dr Harriette Van Spall (McMaster University, CA) to discuss the ARIES HM3 trial.ARIES HM3 is a prospective, randomised, double-blinded, placebo-controlled clinical investigation into heart failure (HF) patients treated with the ARIES HeartMate 3 pump, who were…
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Author(s):
Brian A Bruckner
,
Matthias Loebe
Added:
3 years ago
The use of mechanical circulatory assist devices is rapidly expanding. Patients in advanced stages of heart failure are implanted with support devices, allowing them to regain a fairly normal level of activity. Presently, more then 3,500 patients live with a left ventricular assist device (LVAD). The numbers of patients supported with biventricular assist devices or total artificial hearts is…
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Author(s):
Christopher S Hayward
,
Marc Swartz
Added:
3 years ago
Heart failure is an escalating global pandemic and one of the leading causes of death and disability in the developed world. At present, the incidence of heart failure in the Western world is staggering, affecting approximately 6.5 million people in Europe and 5.8 million people in the US.1–3 Even more alarming is the notion that approximately 10 % of this population suffers from advanced heart…
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Author(s):
Dennis V Cokkinos
,
Christos Belogianneas
Added:
3 years ago
The term cardiac remodelling (REM) is used to define changes that produce geometrical rearrangement of the normal structures of the heart, together with complex biological and molecular alterations. REM affects the heart at the level of the cardiomyocyte, the blood vessels and the extracellular matrix. Proliferation of the latter, resulting in fibrosis, is one of the hallmarks of pathological REM…
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Author(s):
Dominik Wiedemann
,
Thomas Haberl
,
Julia Riebandt
,
et al
Added:
3 years ago
History of Mechanical Circulatory Support
The first reported clinical use of a left ventricular assist device (LVAD) was by Liotta and Crawford in 1963. Via a left thoracotomy, an intracorporeal pneumatically driven pump was implanted using left atrial inflow and descending thoracic aortic outflow. Despite the successful implantation, the patient died within a short period of time after the…
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Author(s):
Patrycja Ganslmeier
,
Christof Schmid
Added:
3 years ago
End-stage heart failure is a leading cause of death of modern society. In the US almost five million people suffer from heart failure, with an annual incidence of 500,000 new cases. About 10% of the population beyond 70 years of age are affected (www.nhlbi.nih.gov). Estimations for Europe amount to 10 million and heart failure has overtaken cancer as the leading cause of death (www.destatis.de)…
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Author(s):
Lee Chang
,
Robert Yeh
Added:
3 years ago
Cardiogenic shock is the leading cause of death in patients with acute ST-elevation myocardial infarction (STEMI). Characterised by a state of low cardiac output leading to end-organ hypoperfusion, cardiogenic shock complicates approximately 5–8 % of STEMIs and is associated with a mortality rate approaching 50 percent.1–3 Prompt recognition and therapeutic intervention for cardiogenic shock due…
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Author(s):
Ricardo Seabra-Gomes
,
Jorge Ferreira
Added:
3 years ago
Cardiogenic shock (CS) is a state of systemic tissue hypoperfusion due to cardiac failure in the presence of adequate intravascular volume.1 Left ventricular pump failure leading to CS remains one of the most serious and challenging conditions over time in cardiology and is still the most common cause of hospital mortality associated with myocardial infarction (MI).2 This review focuses on CS in…
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Author(s):
Kiran K Khush
,
Sharon A Hunt
Added:
3 years ago
The field of heart transplantation has evolved tremendously since Alexis Carrel first explanted a canine heart and anastomosed it to the carotid artery and jugular vein of a recipient dog in 1905.1 In 1960, Norman Shumway and Richard Lower at Stanford described a technique for orthotopic canine heart transplantation and demonstrated adequate physiologic function of the denervated heart.2 Their…
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Author(s):
Antoni Bayés-Genís
,
Christian Muñoz-Guijosa
,
Evelyn Santiago-Vacas
,
et al
Added:
3 years ago
“The time is always right to do what is right.”
– Martin Luther King Jr (1929–1968)
Heart failure (HF) has increased at a fast pace during the 21st century to become the main cause of morbidity and mortality for patients with cardiovascular disorders in developed nations, leading to increasing healthcare costs and declining quality of life. The expected prevalence of HF was ~25 million in 2011,…
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