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Author(s):
Niels Voigt
,
Dobromir Dobrev
Added:
3 years ago
Atrial fibrillation (AF) is common and is associated with significant cardiovascular morbidity and mortality, with stroke being the most critical complication.1,2 Drugs presently used for AF therapy have major limitations, including incomplete efficacy and risks of life-threatening proarrhythmic events (antiarrhythmic drugs) and bleeding complications (anticoagulants).3 Non-pharmacological…
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Cell-specific Mathematical Modelling of hiPSC-CMs and Its Potential for Prediction of Drug Testing
Author(s):
Hirohiko Kohjitani
,
Shigeya Koda
,
Yukiko Himeno
,
et al
Added:
3 years ago
Article
Author(s):
Zenawit Girmatsion
,
Joachim R Ehrlich
Added:
3 years ago
Atrial fibrillation (AF) alters the function of the heart beyond mere changes in cardiac rhythm. It has been associated with untoward clinical outcomes in patients, such as the development of heart failure and stroke. Recent years have brought attention to several aspects of AF-associated alterations termed ‘remodelling’. This article will provide an overview of pertinent aspects of this subject…
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Author(s):
Gheorghe-Andrei Dan
Added:
3 years ago
“The tragedy of science is the slaying of a beautiful hypothesis by ugly facts.”
– Thomas Huxley
The 2016 AF European guidelines specifies that the rhythm control strategy – irrespective of method – exclusively addresses the control of symptoms and improvement of quality of life, autonomy and social functioning.1 The exception, obviously, is the vital indication of acute rhythm restoration in…
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Author(s):
Derk Jan ten Harkel
,
Maarten Witsenburg
Added:
3 years ago
In recent years, there have been many advances in the diagnosis and treatment of arrhythmias in children. This paper focuses on some of these advances, and gives an overview of relevant studies. Special attention is paid to technological advances that have created the possibility of using devices like an implantable loop recorder or an implantable cardioverter-defibrillator (ICD) in even small…
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Author(s):
Hiroshi Watanabe
Added:
3 years ago
Pulmonary arterial hypertension (PAH) is a chronic and life-threatening disease characterised by progressive vascular remodelling that leads to increased pulmonary vascular resistance, right ventricular heart failure and death. PAH is defined by >25 mmHg increase in pulmonary arterial blood pressure and a pulmonary capillary wedge pressure of 15 mmHg.1 If left untreated PAH is fatal; it has a…
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Author(s):
Johannes Mair
Added:
3 years ago
In 1981, de Bold et al.1 provided the definitive demonstration of the endocrine function of the heart by the description of atrial natriuretic peptide (ANP). This was followed by the identification of brain natriuretic peptide, or B-type natriuretic peptide (BNP), in 1988.2,3 This natriuretic peptide (NP) was originally discovered in the porcine brain, but it is synthesised, stored and released…
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Author(s):
Gianfranco Sinagra
,
Michele Moretti
,
Giancarlo Vitrella
,
et al
Added:
3 years ago
According to the latest position statement of the European Society of Cardiology (ESC), cardiomyopathies (CMP) are defined as “myocardial disorders in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disease sufficient to cause the observed myocardial abnormality”.1
CMP may be…
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Author(s):
Tonje A Aksnes
,
Markus P Schneider
,
Sverre E Kjeldsen
,
et al
Added:
3 years ago
The renin–angiotensin system (RAS) has an important role in many cardiovascular diseases, such as hypertension, left ventricular hypertrophy, atherosclerosis and heart failure, and lately its relationship with cardiac arrhythmias has also been investigated.1 Atrial fibrillation is the most frequently occurring sustained cardiac arrhythmia and its prevalence doubles with each advancing decade of…
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Author(s):
Desak Ketut Sekar Cempaka Putri
,
Andrianto Andrianto
,
Makhyan Jibril Al-Farabi
,
et al
Added:
1 year ago