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Author(s): Tomomi Akama , Araya Tenghattakorn , Motoharu Yamasaki , et al Added: 3 years ago
Topic: Heart Failure (Basic), Molecular Cardiology Previous studies, including ours, suggest that tumour repressor p53 is activated during somatic cell reprogramming, and efficiency of induced pluripotent stem cell (iPSC) formation is limited through transactivation of p53 target genes leading to apoptosis and cell cycle arrest. Recent studies revealed non-transcriptional effects of p53 on… View more

Heart Failure
Applications for Induced Pluripotent Stem Cells in Disease Modelling and Drug Development for Heart Diseases
Author(s): Shu Nakao , Dai Ihara , Koji Hasegawa , et al Added: 3 years ago
Induced Pluripotent Stem Cells and Their Potential Applications Induced pluripotent stem cells (iPSCs) are generated from somatic cells, such as skin fibroblasts, by ectopic expression of defined reprogramming factors. Within a few years of the first report of the generation of mouse iPSCs, several laboratories reportedly reproduced these cells using other cell types and species using similar… View more

Vascular Disease and Surgery
Author(s): Daniel Alejandro Lerman , Nasri Alotti , Kiddy Levente Ume , et al Added: 3 years ago
Acute myocardial infarction (AMI) is still a major public health problem worldwide, causing high rates of morbidity and mortality. In the United States, nearly one million patients suffer from AMI each year.1 In the UK, around 80,000 people died from coronary heart disease (CHD) in 2010.2 The current approach to the treatment of myocardial infarction involves early revascularisation with… View more

Vascular Disease and Surgery

Heart Failure
Erectile Dysfunction And Ischaemic Heart Disease
Author(s): Abdalla Ibrahim , Mohamed Ali , Thomas J Kiernan , et al Added: 3 years ago
Erectile dysfunction (ED) is generally defined as the persistent (at least 6 months) inability to achieve and maintain penile erection sufficient to allow satisfactory sexual performance.1 It is a common condition, and recent studies predict a higher prevalence of ED in the future.2 It is estimated that ED has affected more than 150 million men worldwide and this number will reach approximately… View more

MI/ACS
Author(s): Gustav Steinhoff Added: 3 years ago
Cell therapy for myocardial regeneration is an exciting new field of medical research that has the potential to revolutionise cardiovascular medicine. Despite significant improvements in emergency treatment, myocardial infarction (MI) leads to a net loss of contractile tissue in many patients with coronary artery disease (CAD). Often, this is the beginning of a downward spiral towards congestive… View more

Vascular Disease and Surgery

MI/ACS
Author(s): Gustav Steinhoff Added: 3 years ago
Cell therapy for myocardial regeneration is an exciting new field of medical research that has the potential to revolutionize cardiovascular medicine. Despite significant improvements in emergency treatment, myocardial infarction leads to a net loss of contractile tissue in many patients with coronary artery disease. Often, this is the beginning of a downward spiral towards congestive heart… View more

Vascular Disease and Surgery
Author(s): Ali Ghodsizad , Mina Farag , Matthias Loebe , et al Added: 3 years ago
It is estimated that approximately 5 million Americans currently live with heart failure (HF) and an additional 500,000 patients are newly diagnosed each year.1 End-stage HF has a worse prognosis than most types of cancer,2 and heart transplantation remains the gold standard of all therapies for advanced HF.3 However, the number of donor organs significantly fails to meet demand. Therefore,… View more

Vascular Disease and Surgery

MI/ACS
Author(s): Hirohiko Kohjitani , Shigeya Koda , Yukiko Himeno , et al Added: 3 years ago
Topic: Arrhythmia (Basic), Electrophysiology Background Human induced pluripotent stem cells-derived cardiomyocytes (hiPSC-CMs) are expected tool for preclinical evaluation of the safety and efficacy of compounds on the heart. Its action potential (AP) parameters were measured in order to estimate pro-arrhythmic effects of new drugs, mutation of ion-channels, and so on. But, hiPSC-CMs exhibit… View more

Electrophysiology & Arrhythmia
Author(s): Mary N Sheppard Added: 3 years ago
Takotsubo syndrome is an acute reversible heart failure syndrome, which is increasingly recognised by coronary angiography for patients with acute ‘cardiac’ chest pain.1 It is a distinct disease entity from acute coronary syndrome, although the initial presentation has similar features to either ST elevation myocardial infarction (STEMI) or non-ST elevation myocardial infarction (NSTEMI). Early… View more

Heart Failure

Pericardium Disorders
Author(s): Hans P Niendorf , P Lengsfeld , M Bräutigam Added: 3 years ago
Contrast-induced nephropathy (CIN) in the actual essence of the term refers to renal damage induced by a contrast medium. The ultimate clinical manifestation of CIN is renal failure requiring dialysis, and this article will concentrate on CIN as a clinical outcome. However, transient rises in serum creatinine have been frequently used as a surrogate marker that is suggested to predict renal… View more

Imaging & Diagnostics

Prevention & Chronic Conditions