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Author(s): Alessandro Pingitore , Giorgio Iervasi , Francesca Forini Added: 3 years ago
Cardioprotection includes all methods and mechanisms that lead to the reduction in infarct size, and is thus involved in the evolution of post-ischaemic heart failure (HF). This is a growing research issue since ischaemic heart disease is the leading cause of morbidity and mortality worldwide. A key challenge for these studies is the unravelling of cardioprotection complexities such as the… View more

Heart Failure

Prevention & Chronic Conditions
Spontaneous Coronary Artery Dissection: Mechanisms, Diagnosis and Management
Author(s): Marcos Garcia-Guimarães , Teresa Bastante , Paula Antuña , et al Added: 3 years ago
Spontaneous coronary artery dissection (SCAD) can be defined as the acute development of a false lumen within the coronary artery wall that may lead to flow limitation by compression of the true coronary lumen. This definition of SCAD excludes coronary dissections that are secondary to atherosclerotic disease, produced by the extension of an aortic dissection, iatrogenic or related to a trauma.1… View more

MI/ACS
Cardiac Arrhythmias in the Pregnant Woman and the Foetus
Author(s): Hans-Joachim Trappe Added: 3 years ago
Neither supraventricular nor ventricular tachyarrhythmias are uncommon during pregnancy.1,2 When they are diagnosed, patients, relatives and physicians are frequently worried about ectopic beats and sustained arrhythmias.3,4 One should question whether arrhythmias should be treated in the same way as they would be outside pregnancy because all commonly used antiarrhythmic drugs cross the placenta… View more

Demographic
Author(s): Markus Flesch Added: 3 years ago
Introduction Chronic heart failure (HF) is a common, malignant disease and is a major economic burden for healthcare systems in developed nations. It affects 5% to 10% of all people. In Germany, approximately 150,000 people are newly diagnosed with HF per year. Fifteen per cent of approximately 1.6 million HF patients in Germany are in advanced HF status, being classified as stage III-IV… View more

Heart Failure
Author(s): Miriam Shteinshnaider , Dorit Almoznino-Sarafian , Sylvia Berman , et al Added: 3 years ago
Abstract Little is known about gender-related differences in clinical variables affecting the survival in inpatients with atrial fibrillation (AF). We recorded and compared clinical data and long-term mortality between 126 males and 124 females hospitalised with paroxysmal/persistent AF. Women were older and more symptomatic than men. Hypertension and renal dysfunction were more common in… View more

Demographic
Author(s): Rocio Hinojar , Eike Nagel , Valentina O Puntmann Added: 3 years ago
Myocarditis is difficult to diagnose due to its heterogeneous clinical presentation. Patients often present with nonspecific symptoms and there is no easy-to-use and widely available diagnostic test. Although the clinical manifestations of myocarditis are heterogeneous, up to one-third of cases progress toward dilated cardiomyopathy (DCM).1,2 Myocarditis is a major cause of DCM, which is a… View more

Imaging & Diagnostics

Electrophysiology & Arrhythmia
Troponin in Non-ischaemic Dilated Cardiomyopathy
Author(s): Andrea Barison , Luigi Emilio Pastormerlo , Alberto Giannoni Added: 3 years ago
Among the various cardiovascular diseases, non-ischaemic dilated cardiomyopathy (DCM) represents a major cause of morbidity and mortality.1 DCM is characterised by the presence of left ventricular dilatation and systolic dysfunction in the absence of coronary artery disease or abnormal loading conditions (hypertension, valvular disease).2 It originates from several aetiologies and includes… View more

Heart Failure
Current Treatment of Familial Hypercholesterolaemia
Author(s): Cameron T Lambert , Pratik Sandesara , Ijeoma Isiadinso , et al Added: 3 years ago
Familial hypercholesterolaemia (FH) is an autosomal-dominant disorder associated with mutations in the LDL receptor (LDLR) gene resulting in markedly elevated plasma low-density lipoprotein cholesterol (LDL-C) levels and premature atherosclerotic cardiovascular disease (ASCVD). Heterozygous FH (HeFH) (mutation in one allele) is associated with plasma LDL-C levels >190 mg/dl, whereas homozygous… View more

Prevention & Chronic Conditions
Testosterone and the Heart
Author(s): Michael G Kirby , Geoffrey Hackett , Sudarshan Ramachandran Added: 3 years ago
Testosterone deficiency (TD) is a well-established and significant medical condition.1,2 It has been defined as a clinical and biochemical syndrome, associated with older age and comorbidities.3 It is characterised by a deficiency in serum androgen levels, with or without reduced genomic sensitivity to androgens.2 The latter relates to the functionality of androgen receptors. For example, if… View more

Heart Failure

Electrophysiology & Arrhythmia