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Author(s):
Ayumi Katayama
,
Masafumi Funamoto
,
Kana Shimizu
,
et al
Added:
3 years ago
Best Abstract Award – Second prize
Topic: Heart Failure (Basic), Molecular Cardiology
Introduction
A major morphogenic change in heart failure is the hypertrophy of individual cardiomyocytes. Suppressing cardiomyocytes hypertrophy enables the prevention and treatment of heart failure. Although many experimental studies and clinical intervention trials have shown the cardioprotective effect of…
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Author(s):
Yoichi Sunagawa
,
Ayumi Katayama
,
Masafumi Funamoto
,
et al
Added:
2 years ago
Author(s):
Yoichi Sunagawa
,
Masafumi Funamoto
,
Anna Suzuki
,
et al
Added:
3 years ago
Topic: 3. Heart Failure and Cardiomyopathy
Introduction and Objectives
Maladaptive hypertrophy is being recognized as a critical event during the development of heart failure. In a previous study, we demonstrated that a natural compound, curcumin, prevented cardiomyocyte hypertrophy and the development of heart failure in two different model animals.1–4 Recently, we screened a natural…
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Curcumin Analogue GO-Y030 Significantly Improves Pressure Overload-induced Heart Failure in Vivo
Author(s):
Kana Shimizu
,
Masafumi Funamoto
,
Mai Genpei
,
et al
Added:
3 years ago
Article
Curcumin in Lifestyle Diseases
Author(s):
Kana Shimizu
,
Masafumi Funamoto
,
Yoichi Sunagawa
,
et al
Added:
3 years ago
Article
Author(s):
Mai Genpei
,
Yoichi Sunagawa
,
Masafumi Funamoto
,
et al
Added:
3 years ago
Topic: 3. Heart Failure and Cardiomyopathy
Introduction and Objectives
Hemodynamic stimuli such as hypertension and myocardial infarction activate an intracellular signaling pathway, finally reach the nuclei of cardiomyocytes, change the pattern of hypertrophic response gene expressions, and induced cardiac hypertrophy and systolic dysfunction. These eventually lead to the development of…
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Author(s):
Masafumi Funamoto
,
Yoichi Sunagawa
,
Yasufumi Katanasaka
,
et al
Added:
3 years ago
Topic: 3. Heart Failure and Cardiomyopathy
Introduction and Objectives
An intrinsic histone acetyltransferase (HAT), p300, is required for acetylation and the transcriptional activity of GATA4, as well as for pathological left ventricular hypertrophy (LVH) and the development of heart failure (HF) in vivo. Many studies of histone modification have been performed within the flexible tails of…
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Author(s):
Satoshi Shimizu
,
Yoichi Sunagawa
,
Kodai Hara
,
et al
Added:
3 years ago
Topic: Heart Failure (Basic), Molecular Cardiology
Introduction
The zinc finger protein GATA4 is a transcription factor that associates with the intrinsic histone acetyltransferase p300 and regulates myocardial transcriptional activity in response to hypertrophic stimuli. It is known that GATA1, another member of the GATA transcription family, forms a homo-dimer and regulates transcriptional…
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Author(s):
Shigeo Godo
,
Jun Takahashi
,
Satoshi Yasuda
,
et al
Added:
2 years ago
Author(s):
Maciej Banach
,
Yassir Javaid
,
Lale Tokgözoğlu
,
et al
Start date:
May 12, 2022
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