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3 years ago
The majority of all heart attacks and strokes are observed in individuals without elevated cholesterol levels, and some are in those with low cholesterol. Risk factors are absent in approximately 20% of patients with vascular events. If traditional risk factors seem to be unreliable for predicting events in a large number of individuals, expanding the classic risk prediction model would be the…
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3 years ago
Statins are currently the most efficacious and widely prescribed lipid-lowering medications.1 Numerous randomised controlled trials across a spectrum of baseline atherosclerotic cardiovascular disease (ASCVD) risk show that a 1.0 mmol/L (~40 mg/dL) reduction in low-density lipoprotein cholesterol (LDL-C) with statin therapy is associated with an overall 21 % reduction in major vascular events and…
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3 years ago
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3 years ago
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3 years ago
Hypertension is the single most important preventable cause of premature death in the Western world. The quest to find the most effective treatment both in terms of blood pressure control and prevention of events, such as heart attacks and strokes, is on-going. The issue of which antihypertensive agent to use first-line has been the subject of debate for over two decades. The lack of a coherent…
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3 years ago
Familial hypercholesterolaemia (FH) is an autosomal-dominant disorder associated with mutations in the LDL receptor (LDLR) gene resulting in markedly elevated plasma low-density lipoprotein cholesterol (LDL-C) levels and premature atherosclerotic cardiovascular disease (ASCVD). Heterozygous FH (HeFH) (mutation in one allele) is associated with plasma LDL-C levels >190 mg/dl, whereas homozygous…
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Added:
3 years ago
Hypertension is the single most important preventable cause of premature death in the Western world. The quest to find the most effective treatment both in terms of blood pressure control and prevention of events, such as heart attacks and strokes, is on-going. The issue of which antihypertensive agent to use first-line has been the subject of debate for over two decades. The lack of a coherent…
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Added:
3 years ago
Despite the presence of an artificial debate developed in the past decade1,2 focusing on calcium channel blockers and their role in the prevention and treatment of cardiovascular diseases, a huge amount of evidence has been created favouring this class of agents in the treatment of hypertension and associated cardiovascular diseases.3 Calcium channel blockers are divided into three classes, the…
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3 years ago
We are witnessing an epidemic global increase in the prevalence of obesity and its clinical consequences (e.g. insulin resistance and diabetes). This epidemic has been potentiated and sustained by the widespread adoption of unhealthy lifestyles in broad swathes of the population and is characterised by a sedentary lifestyle and an imbalance between the type and characteristics of nutrition,…
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