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Author(s): Christopher R deFilippi , G Michael Felker Added: 3 years ago
Biomarkers have become central to the management of cardiovascular disease, and their potential clinical applications continue to grow. This article reviews galectin-3 (Gal-3), a novel biomarker of fibrosis and remodeling, and its clinical application in heart failure (HF). Case Studies Case Study One A 63-year-old African-American female presents to the emergency department with acute dyspnea… View more

Heart Failure

MI/ACS
Author(s): Yusuke Higuchi , Takehiro Ogata , Masahiro Nishi , et al Added: 3 years ago
Best Abstract Award – First prize Topic: Heart Failure (Basic), Molecular Cardiology Introduction Heart failure (HF) is a debilitating disease associated with high morbidity and mortality. The high mortality rate reflects inadequacy of modern therapy and calls for new mechanistic treatments. A major cause of HF is the adverse tissue remodelling with fibrosis. Excessive extracellular matrix (ECM… View more

Heart Failure
The Natural Product Zerumbone Suppresses Pressure Overload-Induced Cardiac Dysfunction by Inhibiting Cardiac Hypertrophy and Fibrosis
Author(s): Mikuto Tojima , Yasufumi Katanasaka , Yoichi Sunagawa , et al Added: 2 years ago

Prevention & Chronic Conditions
Author(s): Vibeke Marie Almaas , Jan Peder Amlie Added: 3 years ago
Hypertrophic cardiomyopathy (HCM) is a familial disease with a disease-causing mutation in the genes encoding structural components of the cardiac muscle sarcomere in about 60% of cases.1 In a general population of healthy young adults, the prevalence is 1:500.2 The penetrance is incomplete and age-related with a wide clinical spectrum.1 Many patients have normal life expectancy, some die… View more

Heart Failure

MI/ACS
Author(s): Peter P Swoboda , Adam K McDiarmid , Stephen P Page , et al Added: 3 years ago
Inherited cardiomyopathies are primary disorders of the heart muscle that have a genetic basis. On long-term follow-up they are associated with adverse outcomes, particularly sudden death, arrhythmia and heart failure.1 The diagnosis is made on the basis of clinical, cardiac imaging (primarily with transthoracic echocardiography) and genetic features,2 ideally by a tertiary inherited cardiac… View more

Imaging & Diagnostics

Heart Failure
Research Area(s) / Expertise:

Cardio-oncology

Heart Failure

 Job title: Assistant Professor
Dr Giselle Melendez is anAssistant Professor atWake Forest University School of Medicine, Winston-Salem, US.Commencing her scientific career at the University of South Carolina School of Medicine, Dr. Melendez focused on molecular mediators of myocardial extracellular matrix remodeling and heart failure. Notably, her research uncovered vital insights into inflammatory cytokines TNF-α, IL-6, and… View more
Multimodality Imaging to Explore Sex Differences in Aortic Stenosis
Author(s): Gurpreet K Singh , Victoria Delgado Added: 1 year ago

Demographic
Author(s): Sophie Mavrogeni , George Markousis-Mavrogenis , Genovefa Kolovou Added: 3 years ago
Rheumatoid arthritis, the spondyloarthropathies, systemic lupus erythematosus, systemic vasculitides, inflammatory myopathies, systemic sclerosis and mixed connective tissue disease are autoimmune rheumatic diseases (ARDs) with high incidence of cardiovascular disease (CVD).1 CVD is usually underestimated in patients with rheumatic diseases, because the main focus of rheumatologists is the signs… View more

Imaging & Diagnostics
Job title: Director, Interstitial Lung Disease Program
Personal History Dr Gary Matthew Hunninghake is a Pulmonologist and Genetic Epidemiologist based in Boston, MA. Academic History In 1999, Dr Hunninghake received his M.D. from the University of Iowa College of Medicine (now the Roy J. and Lucille A. Carver College of Medicine). He then completed a Residency in Internal Medicine and a Chief Residency (1999 - 2002) at the Medical… View more
A Novel Curcumin Formulation, ASD-Cur, Suppressed the Development of Systolic Dysfunction After Myocardial Infarction in Rats
Author(s): Hidemichi Takai , Yoichi Sunagawa , Masafumi Funamoto , et al Added: 2 years ago

MI/ACS