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Author(s): Gianfranco Sinagra , Michele Moretti , Giancarlo Vitrella , et al Added: 3 years ago
According to the latest position statement of the European Society of Cardiology (ESC), cardiomyopathies (CMP) are defined as “myocardial disorders in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disease sufficient to cause the observed myocardial abnormality”.1 CMP may be… View more

Imaging & Diagnostics

Heart Failure
Author(s): Peter P Swoboda , Adam K McDiarmid , Stephen P Page , et al Added: 3 years ago
Inherited cardiomyopathies are primary disorders of the heart muscle that have a genetic basis. On long-term follow-up they are associated with adverse outcomes, particularly sudden death, arrhythmia and heart failure.1 The diagnosis is made on the basis of clinical, cardiac imaging (primarily with transthoracic echocardiography) and genetic features,2 ideally by a tertiary inherited cardiac… View more

Imaging & Diagnostics

Heart Failure
Author(s): Erwin Oechslin , Rolf Jenni Added: 3 years ago
Non-compaction of the myocardium is gaining prominence as a rare, distinct cardiomyopathy characterised by the presence of numerous, excessive prominent trabeculations and deep intertrabecular recesses which communicate with the left ventricular cavity. Two decades of research have identified a new disease - firstly, its morphologic and clinical characteristics were described on clinical… View more

Heart Failure
Author(s): Erwin Oechslin , Rolf Jenni Added: 3 years ago
Non-compaction of the myocardium is gaining prominence as a rare, distinct cardiomyopathy characterised by the presence of numerous, excessive prominent trabeculations and deep intertrabecular recesses which communicate with the left ventricular cavity. Two decades of research have identified a new disease - firstly, its morphologic and clinical characteristics were described on clinical… View more

Prevention & Chronic Conditions
Applications for Induced Pluripotent Stem Cells in Disease Modelling and Drug Development for Heart Diseases
Author(s): Shu Nakao , Dai Ihara , Koji Hasegawa , et al Added: 3 years ago
Induced Pluripotent Stem Cells and Their Potential Applications Induced pluripotent stem cells (iPSCs) are generated from somatic cells, such as skin fibroblasts, by ectopic expression of defined reprogramming factors. Within a few years of the first report of the generation of mouse iPSCs, several laboratories reportedly reproduced these cells using other cell types and species using similar… View more

Vascular Disease and Surgery
Author(s): Douglas Ewan Cannie , Mohammed Majid Akhtar , Perry Elliott Added: 3 years ago
Heart failure is a global health challenge, affecting 1–2% of the population and up to an estimated 64 million people worldwide.1,2 In the UK, just under 1 million people have heart failure, with approximately 350 new diagnoses each year per 100,000 population.3 The lifetime risk of developing heart failure at 55 years of age is 33% for men and 28% for women.4 The heart failure population is… View more

Heart Failure
AHA 2023 Late-Breaking Science Lineup Revealed
Added: 6 months ago Source:  AHA, Jordan Rance
The American Heart Association has announced eight late-breaking science sessions to be presented in Philadelphia from November 10th to November 13th. AHA is focussed on innovation in cardiovascular disease for scientists, clinicians, researchers and other healthcare professionals. Among the event’s highlights are eight late-breaking trial sessions, as listed below. Watch our coverage of… View more
Author(s): Alessandro Marinelli , Mario Luzi , Alessandro Capucci Added: 3 years ago
Several randomised controlled trials (RCTs) have proven the efficacy of the implantable cardioverter-defibrillator (ICD) in preventing sudden cardiac death (SCD) in patients with advanced systolic heart failure (HF) and reduced left ventricular ejection fraction (LVEF).1–3 ICD therapy proved to be efficacious also in other conditions at high risk for arrhythmic death such as familial SCD… View more

Heart Failure

Electrophysiology & Arrhythmia
Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype?
Author(s): Alexandros Protonotarios , Perry Elliott Added: 3 years ago
Until the 20th century, conventional medicine relied almost exclusively on observable characteristics to classify and treat human disease.1 Even in the modern era, physicians define diseases using phenotypic similarities and employ relatively simple algorithms to interpret diagnostic tools and plan treatment. The advent of low-cost genetic sequencing and its introduction into clinical care… View more

Heart Failure
Sudden Cardiac Death in Athletes
Author(s): Andrew D’Silva , Michael Papadakis Added: 3 years ago
The evidence supporting the beneficial effects of physical activity on health is compelling. Regular exercise reduces cardiovascular mortality by 35 % and all-cause mortality by 33 %1 and confers an average of 7 years greater longevity.2 Most professional athletes, however, undertake doses of exercise that far exceed those recommended by the current evidence, which has been adopted by national… View more

Heart Failure

Electrophysiology & Arrhythmia