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Author(s): Alberto Corsini Added: 3 years ago
Premise Evidence spanning from the pathogenesis of atherosclerosis to epidemiological studies consistently support the direct association of elevated plasma low-density lipoprotein-cholesterol (LDL-C) with the increased risk of cardiovascular disease (CVD). Meta-analysis of 14 trials of statin therapy, with more than 90,000 participants, has shown that each 1mmol/l (39mg/dl) of LDL-C reduction… View more

Prevention & Chronic Conditions
Author(s): Konstantinos Tziomalos , Dimitri P Mikhailidis Added: 3 years ago
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide.1 The relationship between coronary heart disease (CHD) and elevated low-density lipoprotein cholesterol (LDL-C) levels is well established.2 Several large-scale trials, in both primary and secondary prevention settings, have shown that lowering LDL-C levels using statins substantially reduces cardiovascular… View more

Prevention & Chronic Conditions
Author(s): Alberico L Catapano Added: 3 years ago
Introduction Hypercholesterolaemia plays a key role in the development and progression of atherosclerosis and is a proven risk factor for coronary heart disease (CHD).1-4 Therapeutic interventions to lower cholesterol levels both in primary and secondary prevention trials show a clear reduction in the incidence of CHD and stroke.5-11 3-hydroxy-3-methylglutaryl co-enzyme A (HMG-CoA) reductase… View more

Prevention & Chronic Conditions
Author(s): Alberico L Catapano Added: 3 years ago
Introduction Hypercholesterolaemia plays a key role in the development and progression of atherosclerosis and is a proven risk factor for coronary heart disease (CHD).1-4 Therapeutic interventions to lower cholesterol levels both in primary and secondary prevention trials show a clear reduction in the incidence of CHD and stroke.5-11 3-hydroxy-3-methylglutaryl co-enzyme A (HMG-CoA) reductase… View more

Heterogeneous Populations

Prevention & Chronic Conditions
Author(s): Alberico L Catapano Added: 3 years ago
The strong positive correlation between plasma low-density lipoprotein cholesterol (LDL-C) levels and cardiovascular (CV) mortality has been documented beyond any doubt.1 A large body of trials aiming at reducing elevated LDL-C levels also shows that therapeutic intervention results in a proportional reduction of CV events independent of the type of intervention (i.e. diet versus drugs or… View more

Prevention & Chronic Conditions
Author(s): Michel Farnier , John JP Kastelein Added: 3 years ago
Clinical trial evidence from the past two decades has demonstrated that lowering cholesterol levels markedly impacts the occurrence of cardiovascular (CV) disease, including coronary heart disease, a leading cause of mortality and morbidity in the US and Europe.1–7 Data from these studies form the basis of national and international treatment guidelines delineating lipid thresholds and… View more

Prevention & Chronic Conditions
Author(s): Hans-Willi Breuer Added: 3 years ago
Abstract Studies have consistently shown that coronary heart disease (CHD) risk is correlated closely with low density lipoprotein (LDL) cholesterol levels. The lower the LDL cholesterol, the lower the cardiovascular (CV) risk; however, there is a question over how much LDL cholesterol lowering is low enough and what supporting evidence there is for this. This article reviews recent evidence in… View more

Prevention & Chronic Conditions
Low Density Lipoprotein Cholesterol and Coronary Heart Disease - Lower is Better
Author(s): Hans-Willi Breuer Added: 3 years ago
Epidemiology has repeatedly shown that elevated levels of cholesterol play a key role in the development of atherosclerotic disease. In particular, low density lipoprotein (LDL) cholesterol has been strongly associated with coronary heart disease (CHD) risk.1-5 Lowering LDL cholesterol reduces the incidence of atherosclerotic disease, irrespective of how the reduction is achieved. The efficacy of… View more

Prevention & Chronic Conditions
Author(s): Antoni Martínez-Rubio , Román Freixa Pamias Added: 3 years ago
Hypercholesterolemia has been known for several years to be a major risk factor in the development of atherosclerosis and consecutively cardiovascular disease. This epidemiological concept has been widely confirmed using different strategies that have reduced low-density lipoprotein (LDL) levels and cardiovascular events (morbidity and mortality) in primary as well as in secondary prevention, in… View more

Prevention & Chronic Conditions

Demographic
Evolocumab is initiated in Central and Eastern Europe at Much Higher LDL-C Levels than Recommended in Guidelines: Results from the Observational HEYMANS Study
Author(s): V Blaha , R Margoczy , I Petrov , et al Added: 12 months ago

Heart Failure