Search results
Added:
3 years ago
Cardiac resynchronisation therapy (CRT) has been a cornerstone in the treatment of select advanced heart failure cases since its introduction to our armamentarium in the early 2000s.1 Indeed, 30–60% of advanced heart failure patients exhibit evidence of dyssynchrony, when defined electrocardiographically or mechanically.2–4 The latter is a consequence of the former. CRT has several unique…
View more
Added:
3 years ago
The pace of progress in the field of pulmonary arterial hypertension (PAH) continues to be breathtaking. In the past couple of years two new oral agents have been granted licences. Fourteen major international drug trials are underway, many evaluating the role of combination therapies, and at least three agents (simvastatin, imatinib and aviptadil) are undergoing proof of concept studies in…
View more
Added:
2 years ago
Added:
3 years ago
Cardioprotection includes all methods and mechanisms that lead to the reduction in infarct size, and is thus involved in the evolution of post-ischaemic heart failure (HF). This is a growing research issue since ischaemic heart disease is the leading cause of morbidity and mortality worldwide. A key challenge for these studies is the unravelling of cardioprotection complexities such as the…
View more
Added:
3 years ago
Added:
3 years ago
Shortcomings of Traditional Cardiovascular Risk Factors
Many years of epidemiological and clinical cardiovascular research has taught us which risk factors typically lead to the development of cardiovascular disease (CVD). Since the damaging effects of these traditional cardiovascular risk factors are partly additive, researchers have developed different tools to assess cardiovascular risk in…
View more
Added:
10 months ago
Added:
3 years ago
Progressive thickening of the aortic valve leaflets and narrowing of the aortic annulus leads to increased mechanical stress on the left ventricle and reduces cardiac output, resulting in further complications.1–3 The proportion of the population affected increases as the median age of a country or region rises. Approximately 2–4 % of people aged over 65 will develop calcific aortic stenosis,…
View more
Added:
3 years ago
Dietary Patterns
Several studies correlate healthy dietary patterns with lower plasma concentrations of pro-inflammatory markers.1 These healthy dietary patterns support greater benefits than the potential effects of a single nutrient supplementation. The current body of evidence shows that healthy dietary patterns share similarities, shown in Figure 1.2 These features fit with the report of the…
View more
Added:
3 years ago
The notion that atherosclerosis carries features of an inflammatory disease has existed for quite some time. As early as 1856, Rudolf Virchow in his Textbook on Pathology mentioned the term “coronaritis”. Almost 150 years later, following the elucidation of major cardiovascular risk factors in the 1950s Framingham Study, Russell Ross entitled his 1999 review on mechanisms of atherosclerosis …
View more
« First