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Author(s): Jose Luis Zamorano Added: 3 years ago
Heart failure (HF) is a growing and increasingly important chronic disease of the Western world, occurring in at least 2% of the adult population and rising to 3% in those aged over 75 years.1 It is characterised by inadequate systemic perfusion due to impairment of the cardiac pump function. Clinical HF is a progressive condition, typically with high morbidity and mortality rates. It therefore… View more
Dr. Ezekowitz, an accomplished professional in the field of cardiology, serves as the co-director of the Canadian VIGOUR Centre at the University of Alberta. He has spearheaded the establishment of five new heart failure clinics across Alberta to enhance access to specialized services. Furthermore, he plays a pivotal role in co-chairing the heart failure care pathway initiative as part of Alberta… View more
Research Area(s) / Expertise:

Hypertension

Heart Failure

Emeritus Professor of Medicine - Cordoba National University Director - Instituto DAMIC-Fundación Rusculleda, Córdoba, Argentina Fellow of the European Society of Cardiology (FESC) Fellow of the American College of Cardiology (FACC) Past President - International Society of Cardiovascular Pharmacology DrFelipe Martínez is on the Editorial Board of European Cardiology Review. View more
Author(s): Charlotte Eitel , Gerhard Hindricks , Christopher Piorkowski Added: 3 years ago
Cardiac resynchronisation therapy (CRT) is an established therapy for patients with drug-refractory, highly symptomatic systolic heart failure (HF) and delayed ventricular conduction.1 CRT devices are designed to synchronise the mechanical activity within the left ventricle, between the left and the right ventricle and between the atria and ventricles. Resynchronisation induces reverse… View more
Author(s): Jose Luis Zamorano Added: 3 years ago
The clinical and economic impact of heart failure (HF) is well documented. It affects 22 million people worldwide, occurs in at least 2% of the Western adult population and is a progressive condition with high morbidity and mortality rates, placing a significant burden on healthcare resources.3 One of the keys to reducing the clinical and economic impact of HF is accurate and early diagnosis of… View more
Author(s): Josep Lupón , Antoni Bayés-Genís Added: 3 years ago
The left ventricular ejection fraction (LVEF) – calculated as the stroke volume (end-diastolic volume minus end-systolic volume) divided by the end-diastolic volume – remains the main driver for categorising heart failure (HF) and it is a cornerstone in all randomised clinical trials for patients with HF. Although LVEF has many acknowledged limitations, it remains key for the classification,… View more
Author(s): Philip Adamson Added: 3 years ago
A growing appreciation of the prevalence of sleep breathing disorders, especially as co-morbidities of disease syndromes such as chronic heart failure, has increased interest in screening, diagnosis and treatment of obstructive and central sleep apnoea. Sleep apnoea diagnosis currently requires an overnight polysomnograhic evaluation in which the disease is defined as the number of times per hour… View more
Author(s): Miguel Mendes Added: 3 years ago
As far as I know, the designation ‘optimal medical treatment’ was first used by the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial1 investigators as a synonym for the state-of-the-art measures encompassing drug regime, diet and physical activity recommended by the US guidelines for stable angina and acute coronary syndrome (ACS). Looking at the most… View more
Author(s): Giuliano Tocci , Lorenzo Castello , Massimo Volpe Added: 3 years ago
The renin–angiotensin system (RAS) has a key role in the maintenance of cardiovascular (CV) homeostasis, and water and electrolyte metabolism in healthy subjects.1 By contrast, the excess of angiotensin II in several diseases represents a pathophysiological mechanism that can promote or even accelerate atherosclerotic processes, cardiac and vascular hypertrophy, and kidney disease.1 In particular… View more