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Author(s): Sitaramesh Emani , William T Abraham Added: 3 years ago
Heart failure (HF) is a growing epidemiological challenge in the US and worldwide. In the US, it is estimated that at least 5 million people are affected by it, with more than a half-million new diagnosis being made each year.1 Despite major improvements in the treatment of HF, almost 30 % of patients treated for acute HF require readmission within 30 days.2,3 These sobering statistics underscore… View more

Heart Failure

Prevention & Chronic Conditions
Author(s): Roland Wensel , Michael Arzt , Sylvia Montalvan-Dobmayr , et al Added: 3 years ago
Periodic Breathing - Central Sleep Apnoea (CSA) CSA is a periodic waxing and waning of ventilation. In chronic heart failure (CHF), CSA is a result of increased chemoreflex sensitivity, prolonged circulation time (low cardiac output) and low functional residual capacity (Francis et al. Circulation 2000). In CHF, CSA is associated with advanced disease and poor prognosis (Lafranchi et al… View more

Heart Failure

Prevention & Chronic Conditions
Author(s): Philip Adamson Added: 3 years ago
A growing appreciation of the prevalence of sleep breathing disorders, especially as co-morbidities of disease syndromes such as chronic heart failure, has increased interest in screening, diagnosis and treatment of obstructive and central sleep apnoea. Sleep apnoea diagnosis currently requires an overnight polysomnograhic evaluation in which the disease is defined as the number of times per hour… View more

Heart Failure
William T Abraham
Research Area(s) / Expertise:

Heart Failure

 Job title: Professor of Internal Medicine and Chief of the Division of Cardiovascular Medicine
Prof Abraham is a College of Medicine Distinguished Professor. He has been recognized as one of the “Best Doctors in America” for 18 consecutive years.His research has led to the approval/adoption of new heart failure therapies, including beta-blockers, natriuretic peptides, cardiac resynchronization therapy, ultrafiltration, implantable hemodynamic monitoring, transvenous phrenic nerve… View more
Author(s): Holger Woehrle , Jochen Müller-Ehmsen , Erland Erdmann Added: 3 years ago
Abstract Sleep-disordered breathing (SDB) is a common finding in patients with cardiovascular disease (CVD). SDB can cause negative effects on the cardiovascular system and can contribute to the worsening of the underlying disease. Obstructive sleep apnoea (OSA) is a major independent risk factor for the manifestation and progression of cardiovascular diseases, whereas central sleep apnoea (CSA)… View more

Electrophysiology & Arrhythmia

Prevention & Chronic Conditions
Author(s): Masaaki Takeuchi , Nobuhiko Haruki , Yutaka Otsuji Added: 3 years ago
More than half of the patients with chronic heart failure (CHF) have associated sleep-disordered breathing (SDB), which consists of either obstructive sleep apnoea (OSA) or central sleep apnoea (CSA).1,2 SDB has deleterious effects on systolic and diastolic ventricular function. In patients with CHF, the presence of SDB results in a poorer prognosis;3,4 thus, its early recognition and adequate… View more

Imaging & Diagnostics

Heart Failure
Author(s): Simon G Pearse , Martin R Cowie , Rakesh Sharma , et al Added: 3 years ago
Despite advances in therapy, heart failure (HF) continues to be a leading cause of hospitalisation in those over 65.1 Around 2 % of people in Europe live with HF and as many as 10 % of those over 75 years are affected.2 Prognosis continues to be poor, with approximately half of patients dying within 5 years of first hospitalisation,3 a more severe prognosis than many malignancies.4 Sleep… View more

Heart Failure
APSC Consensus on OSA in CVD Patients
Author(s): Jack Wei Chieh Tan , Leong Chai Leow , Serene Wong , et al Added: 1 year ago

Prevention & Chronic Conditions

CV Disease in Special Populations
Cardiovascular Management of Adults with Marfan Syndrome
Author(s): Yukiko Isekame , Sabiha Gati , Jose Antonio Aragon-Martin , et al Added: 3 years ago
Marfan syndrome (MFS) is a disease in which connective tissue becomes weak secondary to fibrillin-1 mutations, resulting in aortic dilatation, aneurysm formation, aortic dissection, aortic regurgitation and mitral valve prolapse (MVP; see Table 1). Epidemiology MFS is an autosomal dominant condition: 75 % of all patients inherit the condition from one affected parent and 25 % are affected as… View more

Vascular Disease and Surgery

Electrophysiology & Arrhythmia
ESC 22: ADVENT-HF: Adaptive Servo Ventilation in Pts with HF ＆ Sleep Apnea
Author(s): Douglas Bradley Added: 1 year ago
ESC 22 - In this short interview filmed onsite at ESC Congress 2022, Dr Douglas Bradley (University of Toronto, Toronto, CA) discusses the findings of the ADVENT-HF Trial (NCT01128816). ADVENT-HF was designed to determine if a respiratory device, Adaptive Servo Ventilation can reduce the risk of cardiovascular hospitalisations and death in patients with heart failure and sleep apnoea. 732… View more

Heart Failure

Prevention & Chronic Conditions