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Author(s): Ayumi Katayama , Masafumi Funamoto , Kana Shimizu , et al Added: 3 years ago
Best Abstract Award – Second prize Topic: Heart Failure (Basic), Molecular Cardiology Introduction A major morphogenic change in heart failure is the hypertrophy of individual cardiomyocytes. Suppressing cardiomyocytes hypertrophy enables the prevention and treatment of heart failure. Although many experimental studies and clinical intervention trials have shown the cardioprotective effect of… View more

Heart Failure
Author(s): Yasufumi Katanasaka , Masatoshi Namiki , Yoichi Sunagawa , et al Added: 3 years ago
Topic: Heart Failure (Basic), Molecular Cardiology Cardiac hypertrophy is a risk factor for the development of heart failure. To elucidate underlying molecular mechanism is necessary for the development of novel pharmacological therapy targeting to pathological cardiac hypertrophy. We have previously reported that the acetylation of GATA4 by p300 is essential for cardiomyocyte hypertrophy and… View more

Heart Failure
Author(s): Satoshi Shimizu , Yoichi Sunagawa , Kodai Hara , et al Added: 3 years ago
Topic: Heart Failure (Basic), Molecular Cardiology Introduction The zinc finger protein GATA4 is a transcription factor that associates with the intrinsic histone acetyltransferase p300 and regulates myocardial transcriptional activity in response to hypertrophic stimuli. It is known that GATA1, another member of the GATA transcription family, forms a homo-dimer and regulates transcriptional… View more

Heart Failure
The Polyunsaturated Fatty Acids EPA and DHA Prevent Myocardial Infarction-induced Heart Failure by Inhibiting p300-HAT Activity in Rats
Author(s): Yoichi Sunagawa , Ayumi Katayama , Masafumi Funamoto , et al Added: 2 years ago

Heart Failure

MI/ACS
Author(s): Kazuma Hanajima , Yusuke Miyazaki , Yasufumi Katanasaka , et al Added: 3 years ago
Topic: Heart Failure (Clinical), Cardiomyopathy, Myocarditis Background The mortality of heart disease has been increasing in all over the world. Cardiac hypertrophy is an important risk factor for heart failure. We have previously reported that protein arginine methyltransferase 5 (PRMT5) specific inhibitor EPZ015666 (EPZ) suppressed cardiomyocyte hypertrophy in neonatal rat cardiomyocytes… View more

Heart Failure
Compound A, a Ginger Extract, Significantly Reduces Pressure Overload-induced Systolic Heart Failure in Mice
Author(s): Yuto Kawase , Kana Shimizu , Masafumi Funamoto , et al Added: 2 years ago

Heart Failure
Discovery of Novel Small Molecules for Heart Failure Therapy Using Cultured Cardiomyocyte by High Throughput Screening Assay
Author(s): Satoshi Shimizu , Miho Yamada , Takahiro Katagiri , et al Added: 2 years ago

Heart Failure
Author(s): Yoichi Sunagawa , Masafumi Funamoto , Anna Suzuki , et al Added: 3 years ago
Topic: 3. Heart Failure and Cardiomyopathy Introduction and Objectives Maladaptive hypertrophy is being recognized as a critical event during the development of heart failure. In a previous study, we demonstrated that a natural compound, curcumin, prevented cardiomyocyte hypertrophy and the development of heart failure in two different model animals.1–4 Recently, we screened a natural… View more

Heart Failure
Author(s): Masafumi Funamoto , Yoichi Sunagawa , Yasufumi Katanasaka , et al Added: 3 years ago
Topic: 3. Heart Failure and Cardiomyopathy Introduction and Objectives An intrinsic histone acetyltransferase (HAT), p300, is required for acetylation and the transcriptional activity of GATA4, as well as for pathological left ventricular hypertrophy (LVH) and the development of heart failure (HF) in vivo. Many studies of histone modification have been performed within the flexible tails of… View more

Heart Failure
Author(s): Kana Shimizu , Masafumi Funamoto , Mai Genpei , et al Added: 3 years ago
Topic: 3. Heart Failure and Cardiomyopathy Introduction and Objectives Signals activated by increased hemodynamic overload to the heart finally reach the nuclei of cardiac myocytes and induce maladaptive hypertrophy in them. Nuclear acetylation, which is controlled by histone deacetylases and the intrinsic histone acetyltransferase p300, is a critical event in this process. We previously… View more

Heart Failure