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Author(s):
Gheorghe-Andrei Dan
Added:
3 years ago
“The tragedy of science is the slaying of a beautiful hypothesis by ugly facts.”
– Thomas Huxley
The 2016 AF European guidelines specifies that the rhythm control strategy – irrespective of method – exclusively addresses the control of symptoms and improvement of quality of life, autonomy and social functioning.1 The exception, obviously, is the vital indication of acute rhythm restoration in…
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Author(s):
Shu Nakao
,
Dai Ihara
,
Koji Hasegawa
,
et al
Added:
3 years ago
Induced Pluripotent Stem Cells and Their Potential Applications
Induced pluripotent stem cells (iPSCs) are generated from somatic cells, such as skin fibroblasts, by ectopic expression of defined reprogramming factors. Within a few years of the first report of the generation of mouse iPSCs, several laboratories reportedly reproduced these cells using other cell types and species using similar…
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Author(s):
Lori L McMullan
,
Gaston Vergara
,
Nassir F Marrouche
Added:
3 years ago
Atrial fibrillation (AF) and heart failure (HF) are two disease conditions that are intimately intertwined, both pathophysiologically and clinically. Currently, over 2.3 million people in North America and 4.5 million in the EU have AF, making it the most common arrhythmia encountered in clinical practice.1,2 It is expected that by 2050 there will be over 10 million people with AF.3 The estimated…
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Author(s):
Gilles W De Keulenaer
,
Dirk L Brutsaert
Added:
3 years ago
Definitions and Historical Considerations – The Misleading Role of Ejection Fraction
Chronic heart failure (CHF) is a heterogeneous syndrome with a complex pathophysiology. Although many different definitions for heart failure exist, we prefer the following: “a clinical syndrome characterised by symptoms and signs of increased tissue/organ water and decreased tissue/organ perfusion. Regardless…
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Author(s):
Niels Voigt
,
Dobromir Dobrev
Added:
3 years ago
Atrial fibrillation (AF) is common and is associated with significant cardiovascular morbidity and mortality, with stroke being the most critical complication.1,2 Drugs presently used for AF therapy have major limitations, including incomplete efficacy and risks of life-threatening proarrhythmic events (antiarrhythmic drugs) and bleeding complications (anticoagulants).3 Non-pharmacological…
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Author(s):
Christos-Konstantinos Antoniou
,
Panagiota Manolakou
,
Nikolaos Magkas
,
et al
Added:
3 years ago
Cardiac resynchronisation therapy (CRT) has been a cornerstone in the treatment of select advanced heart failure cases since its introduction to our armamentarium in the early 2000s.1 Indeed, 30–60% of advanced heart failure patients exhibit evidence of dyssynchrony, when defined electrocardiographically or mechanically.2–4 The latter is a consequence of the former. CRT has several unique…
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Author(s):
Marco Metra
,
Savina Nodari
,
Livio Dei Cas
Added:
3 years ago
Beta-blocker therapy remains one of the most fascinating issues in heart failure (HF) clinical practice. These agents, once absolutely contraindicated in patients with HF, have been shown to have the greatest beneficial effects on the patients' prognosis. They have radically changed the clinical course of HF, more than any other agent previously introduced, and are now the cornerstone of current…
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Author(s):
Marco Metra
,
Savina Nodari
,
Livio Dei Cas
Added:
3 years ago
Beta-blocker therapy remains one of the most fascinating issues in heart failure (HF) clinical practice. These agents, once absolutely contraindicated in patients with HF, have been shown to have the greatest beneficial effects on the patients' prognosis. They have radically changed the clinical course of HF, more than any other agent previously introduced, and are now the cornerstone of current…
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Author(s):
Zenawit Girmatsion
,
Joachim R Ehrlich
Added:
3 years ago
Atrial fibrillation (AF) alters the function of the heart beyond mere changes in cardiac rhythm. It has been associated with untoward clinical outcomes in patients, such as the development of heart failure and stroke. Recent years have brought attention to several aspects of AF-associated alterations termed ‘remodelling’. This article will provide an overview of pertinent aspects of this subject…
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Author(s):
Andrea Barison
,
Luigi Emilio Pastormerlo
,
Alberto Giannoni
Added:
3 years ago
Among the various cardiovascular diseases, non-ischaemic dilated cardiomyopathy (DCM) represents a major cause of morbidity and mortality.1 DCM is characterised by the presence of left ventricular dilatation and systolic dysfunction in the absence of coronary artery disease or abnormal loading conditions (hypertension, valvular disease).2 It originates from several aetiologies and includes…
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