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Author(s): Michael Joner Added: 5 months ago
In this interview, Prof Michael Joner (German Heart Centre, Munich, DE) discusses the specific needs and treatment considerations when managing low and intermediate risk TAVI patients. He also highlights the increasing need to consider future interventions when selecting the index valve.Prof Joner details the Navitor TAVI system resheathable design with intra-annular function, large-cell frame… View more
Author(s): Barbara McGowan Added: 2 years ago
ECO 2024 — Prof Barbara McGowan (Guy's and St Thomas' Hospital & King's College, UK) joins us to discuss the findings from the STEP 10 trial (NCT05040971, Novo Nordisk).This Phase 3 randomised clinical trial investigated the efficacy and safety of subcutaneous semaglutide 2.4 mg (GLP-1 RA) in 181 participants with obesity (BMI greater than or equal to 30.0 kg/m^2) and prediabetes. The primary… View more
Added: 10 months ago Source:  Radcliffe CVRM
A secondary analysis of the SUMMIT trial has found that the benefits of tirzepatide on reducing the risk of cardiovascular death or worsening heart failure (HF) are consistent across all levels of obesity in patients with heart failure with preserved ejection fraction (HFpEF).¹ However, patients with a higher baseline body mass index (BMI) experienced greater improvements in exercise capacity and… View more
Added: 10 months ago Source:  Radcliffe CVRM
A new multi-ancestry polygenic score (PGS) for body mass index (BMI), developed using genetic data from over 5.1 million people, substantially improves the prediction of obesity across the life course compared to previous scores.¹ The research, which drew data from the GIANT consortium and 23andMe, demonstrates particular value in predicting obesity risk from early childhood and in understanding… View more