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Author(s): Jacob George , Thomas M MacDonald Added: 3 years ago
Hypertension increases the risk of heart attack, stroke, kidney disease, and heart failure1 and is the leading preventable risk factor for global cardiovascular (CV) disease burden worldwide.2 At ages 40–69 years, each increase of 20 mmHg in systolic blood pressure (BP) is associated with more than a doubling of the baseline mortality rate from cardiovascular disease (CVD).3 However, despite the… View more
Job title: Research Fellow
Personal History Dr Isabella Tan is a software programmer turned cardiovascular research scientist. She is a Research Fellow at the Macquarie Medical School, Macquarie University, Sydney.2 She enjoys watching Japanese anime and reading manga. In addition to English, she speaks Cantonese and Mandarin.1, 4 Academic History In 2003, Dr Tan graduated from the University of New South… View more
Author(s): Alexandre Persu , Fadl Elmula M Fadl Elmula , Yu Jin , et al Added: 3 years ago
Renal sympathetic denervation (RDN) has been introduced as a novel approach to treat patients with so-called resistant hypertension.1–3 The first randomised clinical trial showed an impressive 32/12 mmHg fall in blood pressure after six months in the intervention group (n=52) compared to the control group (n=54). However, with the recent publication of the Symplicity HTN-3 study in the US4 the… View more
Author(s): Isla S Mackenzie , Thomas M MacDonald Added: 3 years ago
Hypertension becomes more common with increasing age. As we gradually move towards having a higher proportion of elderly people in the population, greater numbers of octogenarians are being treated for hypertension. In this article we describe the main features of hypertension in the elderly and describe some of the particular issues that affect elderly patients. We also discuss the results of… View more
Author(s): Stefano Taddei , Rosa Maria Bruno Added: 3 years ago
The concept of resistant hypertension (RH) has received great attention in the past years, mainly as a possible target population for innovative therapeutic strategies. An increasing number of original articles and commentaries have focused on the clinical significance, prognosis and treatment of this condition. Thus it is not surprising than even its definition is still a matter of debate,… View more
Author(s): Francesco P Cappuccio Added: 3 years ago
Hypertension is a major independent risk factor for cardiovascular (CV) diseases, including cardiac death, coronary heart disease, heart failure, stroke and chronic kidney disease. Therefore, early diagnosis, prevention and optimal management of hypertension is essential.1 Hypertension poses a growing public health burden: the number of adults with elevated blood pressure (BP) increased from 594… View more
Author(s): Valérie E Stegehuis , Gilbert WM Wijntjens , Tadashi Murai , et al Added: 3 years ago
The emphasis in ischaemic heart disease (IHD) diagnosis has historically been directed towards the identification of epicardial coronary stenosis by selective coronary angiography, and its management by percutaneous coronary intervention (PCI) or coronary bypass graft surgery. Over the past two decades, the application of coronary physiology techniques to identify the haemodynamic severity of… View more
Author(s): Mario Petretta , Pierluigi Costanzo , Alberto Cuocolo Added: 3 years ago
Myocardial blood flow (MBF) must respond to changes in metabolic conditions and oxygen requests to meet the needs of myocytes, and autoregulation plays a mayor role in the control of coronary circulation.1–3 It has been demonstrated that, as a coronary artery is progressively narrowed, resting flow does not change at first, but maximal flow (achieved by injecting a vasodilator) decreases… View more