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ESC 22: Dosing of Asundexian in Pts With Non-Cardioembolic Ischemic Stroke
Author(s): Ashkan Shoamanesh Added: 1 year ago
ESC Congress 22 — Prof Ashkan Shoamanesh (McMaster University, CA) reveals the findings of the PACIFIC-STROKE trial (NCT04304508). This multicenter study aims to find the best dose of oral FXIa inhibitor, asundexian (Bayer). 1808 patients with non-cardioembolic ischemic stroke were included in this trial, and were randomized to receive different doses of asundexian. Questions: What doses were… View more

Anticoagulation

Prevention & Chronic Conditions
Author(s): Nobutoyo Masunaga , Shuichi Ura , Mitsuru Ishii , et al Added: 3 years ago
Topic: Atherosclerosis (Clinical), Cardiac Catheterisation The lymphatic system has been suggested to play an important role in cholesterol metabolism and cardiovascular disease. Vascular endothelial growth factor-C (VEGF-C) plays a key role in lymphangiogenesis. Recently, we demonstrated that VEGF-C is closely associated with dyslipidaemia and atherosclerosis. However, the relationship between… View more

Electrophysiology & Arrhythmia

Prevention & Chronic Conditions
ESC 23: OCEAN(a)-DOSE Trial Update
Author(s): Michelle O'Donoghue Added: 7 months ago
ESC 23 — Dr Michelle O'Donoghue (Brigham and Women's Hospital, US) outlines a trial update from OCEAN(a)-Dose Extension trial (NCT05581303) in this succinct interview. OCEAN(a)-DOSE (Amgen) was a dose-finding study aiming to evaluate a siRNA, olpasiran, and its effect on risk for coronary heart disease death, myocardial infarction or urgent coronary revascularization when administered… View more

Prevention & Chronic Conditions
Paul M Ridker
Job title: Senior Physician, Brigham and Women's Hospital Eugene Braunwald Professor of Medicine, Harvard Medical School
Dr Paul M Ridker is director of the Center for Cardiovascular Disease Prevention, a translational research unit at Brigham and Women’s Hospital (BWH). A cardiovascular medicine specialist, he is also the Eugene Braunwald Professor of Medicine at Harvard School of Medicine (HMS). Dr Ridker received his medical degree from HMS. He then completed an internal medicine residency and a cardiology… View more
Author(s): Andrew Carson Added: 3 years ago
For many years cardiovascular disease has been a major cause of morbidity and mortality across the developed world, and its incidence is also increasing in many developing countries. Indeed, it has recently been shown that even Egyptian mummies, representing the more affluent members of their society several thousand years ago, had established atherosclerosis in multiple blood vessels.1… View more

Prevention & Chronic Conditions
Thomas Kahan
Research Area(s) / Expertise:
Dr Thomas Kahan is Senior consultant in cardiolgy at the Department of cardiology, Danderyd University Hospital Dr Kahan is on the Editorial Board of European Cardiology Review. Research Interests Neurohormonal control of blood pressure and cardiac function in man. Specifically, we study how the sympatho-adrenal mechanisms and the renin-angiotensin-aldosterone system influence… View more
Author(s): Mattia Cattaneo , Alberto Froio , Augusto Gallino Added: 3 years ago
Imaging has played an instrumental role in the diagnostic and prognostic assessment of cardiovascular diseases. Arterial Doppler ultrasound, echocardiography, myocardial perfusion imaging tests and angiography are now part of everyday clinical practice and represent a cornerstone of atherosclerosis management.1 During the past two decades, there has been an expansion of the available imaging… View more

Imaging & Diagnostics
Late breaking Clinical Trial Data Addressing Cardiovascular Outcomes in Patients with Diabetes presented at American College of Cardiology Congress
Added: 1 week ago Source:  Radcliffe Cardiology, Greg Guillory
Two late-breaking clinical trials addressing cardiovascular outcomes in patients with diabetes were presented this week at the American College of Cardiology meeting in Atlanta, USA. One of these trials looked at the effects of the hyperactivation of the polyol pathway on diabetic cardiomyopathy (DbCM) and the other the effects of chelation therapy in patients with diabetes and prior myocardial… View more
Author(s): Maki Komiyama , Hiromichi Wada , Hajime Yamakage , et al Added: 3 years ago
Best Poster Award Topic: 1. Clinical Cardiology Introduction and Objectives Vessel wall Inflammation promotes the destabilization of atherosclerotic plaques. The lectin-like oxidized low- density lipoprotein (LDL) receptor-1 (LOX-1) expressed by vascular cells and monocytes. LOX index is calculated by multiplying LOX-1 ligand containing apolipoprotein B level with the soluble LOX-1. A high… View more

Heart Failure

Prevention & Chronic Conditions
Author(s): Koji Hasegawa Added: 3 years ago
Myocardial infarction is often caused by the rupture of unstable plaque in atherosclerosis with mild-to-moderate stenosis. Research has revealed that local tissue inflammation is closely involved in the rupture of atherosclerotic plaque.1 Stabilization of atherosclerotic plaque by strictly managing the risk factors for coronary artery disease is a crucial strategy to prevent the recurrence of… View more

Heart Failure

Prevention & Chronic Conditions