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Author(s):
Franz H Messerli
,
Georg Noll
,
Lars H Lindholm
,
et al
Added:
3 years ago
Recent evidence supports a central role for calcium channel blockers (CCBs), and in particular the dihydropyridine (DHP) agents, in the treatment of hypertension and cardiovascular disease (CVD). We review here the findings of recent trials, systematic reviews and meta-analyses that rebut those of the single, yet widely-publicised, earlier unfavourable meta-analysis. In these latest reports, CCBs…
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Author(s):
Roland E Schmieder
Added:
3 years ago
The primary goal in the treatment of hypertensive patients is to achieve the maximum possible reduction in the long-term total risk of cardiovascular (CV) and renal morbidity and mortality. In addition to the lowering of blood pressure (BP) per se, successful realisation of the primary goal of treatment also requires appropriate consideration of co-morbidities.1–3 Although there is some…
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Author(s):
Roland E Schmieder
Added:
3 years ago
It is widely acknowledged that effective management of hypertension – even if blood pressure (BP) is reduced by only 2mmHg – can significantly reduce the incidence of stroke, myocardial infarction (MI) and heart failure (HF).1 However, despite the wide range of conventional antihypertensive agents available, approximately 70% of patients fail to achieve adequate BP control.2 Furthermore, although…
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Author(s):
Franz H Messerli
,
Georg Noll
,
Lars H Lindholm
,
et al
Added:
3 years ago
Recent evidence supports a central role for calcium channel blockers (CCBs), and in particular the dihydropyridine (DHP) agents, in the treatment of hypertension and cardiovascular disease (CVD). We review here the findings of recent trials, systematic reviews and meta-analyses that rebut those of the single, yet widely-publicised, earlier unfavourable meta-analysis.1 In these latest reports,…
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Author(s):
Felix Mahfoud
Added:
1 year ago
In this short late-breaking interview, Prof Felix Mahfoud (Saarland University Hospital, DE) discusses the 3-year efficacy outcomes of the SPYRAL HTN-ON MED Pilot Study (NCT02439775). The global clinical study, presented at ACC.22, tested the long-term effect of renal denervation (Symplicity Spyral™ multi-electrode renal denervation system, Medtronic Vascular) on blood pressure reduction in…
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Author(s):
Sverre E Kjeldsen
Added:
3 years ago
Hypertension affects approximately 26% of adults globally and is a leading risk factor for cardiovascular disease and death. The renin system is central to blood pressure (BP) control, and chronic activation of the system, as occurs in pathological conditions, leads to damage to organs (such as the heart and kidneys), as well as perpetuating elevated BP. Identification of the pivotal role played…
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Author(s):
Alejandro de la Sierra
Added:
3 years ago
Despite the presence of an artificial debate developed in the past decade1,2 focusing on calcium channel blockers and their role in the prevention and treatment of cardiovascular diseases, a huge amount of evidence has been created favouring this class of agents in the treatment of hypertension and associated cardiovascular diseases.3 Calcium channel blockers are divided into three classes, the…
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Author(s):
Patricia Fonseca
,
Anna F Dominiczak
,
Stephen Harrap
,
et al
Added:
3 years ago
Abstract
Early combination therapy is more effective for hypertension control in high-risk patients than monotherapy, and current guidelines recommend the use of either an angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) for first-line therapy in patients younger than 55 years. Recent evidence shows that ACEIs reduce mortality, whereas ARBs show no apparent…
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Author(s):
Michel Burnier
Added:
3 years ago
In 2007, the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC) published their guidelines for the management of arterial hypertension.1 These guidelines covered in detail all aspects of the management of hypertensive patients, from the diagnosis and detection of early subclinical organ damage to the discussion of the various therapeutic strategies in essential…
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Author(s):
Alejandro de la Sierra
Added:
3 years ago
The Concepts of Metabolic Syndrome and Cardiometabolic Risk
Cardiometabolic risk represents a situation where the possibilities of developing atherosclerotic cardiovascular disease and diabetes are significantly enhanced as a consequence of the presence of insulin resistance and atherogenic dyslipidaemia. Dyslipidaemia is characterised by the presence of low high-density lipoprotein (HDL)…
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