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Author(s):
Nilofer Sorathia
,
Hussein Al-Rubaye
,
Benham Zal
Added:
3 years ago
Statins are most frequently prescribed for the primary prevention of cardiovascular disease due to their lipid-lowering properties. They are known to exert their effect by competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. The reduction in the synthesis of cholesterol induces upregulation of LDL receptors in the liver, resulting in increased clearance and…
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Author(s):
Wolfgang Koenig
Added:
3 years ago
The notion that atherosclerosis carries features of an inflammatory disease has existed for quite some time. As early as 1856, Rudolf Virchow in his Textbook on Pathology mentioned the term “coronaritis”. Almost 150 years later, following the elucidation of major cardiovascular risk factors in the 1950s Framingham Study, Russell Ross entitled his 1999 review on mechanisms of atherosclerosis …
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Author(s):
David Antoniucci
Added:
3 years ago
In the setting of acute myocardial infarction (AMI), spontaneous and percutaneous coronary intervention (PCI)-related embolisation results in a decreased efficacy of mechanical reperfusion and myocardial salvage. Direct stenting without predilation may decrease embolisation and the incidence of the no-reflow phenomenon.1,2 More specific approaches to the problem of microvessel embolisation during…
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Author(s):
Gustav Steinhoff
Added:
3 years ago
Cell therapy for myocardial regeneration is an exciting new field of medical research that has the potential to revolutionize cardiovascular medicine. Despite significant improvements in emergency treatment, myocardial infarction leads to a net loss of contractile tissue in many patients with coronary artery disease. Often, this is the beginning of a downward spiral towards congestive heart…
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Author(s):
Ahmed Zwain
,
Mohanad Aldiwani
,
Hussein Taqi
Added:
2 years ago
Author(s):
Esther Godfrey
,
Julian PJ Halcox
Added:
3 years ago
Atherosclerotic cardiovascular disease (CVD) is a global epidemic. As life expectancy has increased, chronic degenerative diseases have become a significant healthcare burden, affecting developed and developing countries alike,1 with atherosclerotic disease the leading cause of death according to the WHO.2 The development of effective strategies for the prevention of cardiovascular events at…
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Author(s):
Francesco Condello
,
Matteo Sturla
,
Bernhard Reimers
,
et al
Added:
2 years ago
Author(s):
Miguel Mendes
Added:
3 years ago
As far as I know, the designation ‘optimal medical treatment’ was first used by the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial1 investigators as a synonym for the state-of-the-art measures encompassing drug regime, diet and physical activity recommended by the US guidelines for stable angina and acute coronary syndrome (ACS). Looking at the most…
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Author(s):
Christoph Maack
,
Michael Böhm
Added:
3 years ago
Chronic heart failure is the leading cause of hospitalisation in Germany1 and other European countries. It is the result of various cardiovascular diseases, such as myocardial infarction, arterial hypertension and valvular heart diseases. About 50 % of patients with heart failure have normal systolic, but impaired diastolic function, a condition termed heart failure with preserved ejection…
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Author(s):
Marinela Beznă
,
Gabriela Mitoaica
,
Lorena Ungureanu
,
et al
Added:
11 months ago