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Author(s): Rocio Hinojar , Eike Nagel , Valentina O Puntmann Added: 3 years ago
Myocarditis is difficult to diagnose due to its heterogeneous clinical presentation. Patients often present with nonspecific symptoms and there is no easy-to-use and widely available diagnostic test. Although the clinical manifestations of myocarditis are heterogeneous, up to one-third of cases progress toward dilated cardiomyopathy (DCM).1,2 Myocarditis is a major cause of DCM, which is a… View more
Author(s): Sotirios Tsalamandris , Alexios S Antonopoulos , Evangelos Oikonomou , et al Added: 3 years ago
Diabetes is a multifaceted metabolic disorder affecting the glucose status of the human body. Impaired glucose tolerance and hyperglycaemia are the main clinical and diagnostic features and the result of an absolute or relative insulin deficiency or resistance to its action. Chronic hyperglycaemia associated with diabetes can result in end organ dysfunction and failure which can involve the… View more
Author(s): Kerry Layne , Albert Ferro Added: 3 years ago
Acute coronary syndrome (ACS) is a term used to encompass unstable angina (UA) and myocardial infarction (MI) with or without electrocardiographic (ECG) evidence of ST-segment elevation. Antiplatelet therapy has formed the backbone of ACS management for decades and the drug class continues to evolve as novel agents with increasingly efficacious antiplatelet actions are identified. The main risk… View more
Author(s): Alberto Lorenzatti , Maria Luz Servato Added: 3 years ago
Coronary artery disease (CAD) is the leading cause of death in most countries. Compelling evidence from epidemiological, genetic and clinical studies as well as experiments in animal models has unquestionably established that elevated concentrations of cholesterol (mainly transported by LDL particles) promote atherosclerotic lesions.1 Although statin-based lipid-lowering therapies have been shown… View more
Author(s): Kana Shimizu , Masafumi Funamoto , Yoichi Sunagawa , et al Added: 3 years ago
Inflammation involves an array of processes in response to tissue damage resulting from oxidative stress or other causes and triggers repair, such as subsequent extracellular matrix remodelling and fibrosis.1–3 Chronic inflammation continues for a prolonged period, lasting from several months to several years, and is characterised by tissue invasion by inflammatory macrophages. This induces the… View more