Search results
Author(s):
Peter J Lansberg
Added:
3 years ago
The majority of all heart attacks and strokes are observed in individuals without elevated cholesterol levels, and some are in those with low cholesterol. Risk factors are absent in approximately 20% of patients with vascular events. If traditional risk factors seem to be unreliable for predicting events in a large number of individuals, expanding the classic risk prediction model would be the…
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Author(s):
Koji Hasegawa
Added:
3 years ago
Myocardial infarction is often caused by the rupture of unstable plaque in atherosclerosis with mild-to-moderate stenosis. Research has revealed that local tissue inflammation is closely involved in the rupture of atherosclerotic plaque.1 Stabilization of atherosclerotic plaque by strictly managing the risk factors for coronary artery disease is a crucial strategy to prevent the recurrence of…
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Author(s):
Kazeen Abdullah
,
Anand Rohatgi
Added:
3 years ago
Statins are currently the most efficacious and widely prescribed lipid-lowering medications.1 Numerous randomised controlled trials across a spectrum of baseline atherosclerotic cardiovascular disease (ASCVD) risk show that a 1.0 mmol/L (~40 mg/dL) reduction in low-density lipoprotein cholesterol (LDL-C) with statin therapy is associated with an overall 21 % reduction in major vascular events and…
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Author(s):
Kerry Layne
,
Albert Ferro
Added:
3 years ago
Acute coronary syndrome (ACS) is a term used to encompass unstable angina (UA) and myocardial infarction (MI) with or without electrocardiographic (ECG) evidence of ST-segment elevation. Antiplatelet therapy has formed the backbone of ACS management for decades and the drug class continues to evolve as novel agents with increasingly efficacious antiplatelet actions are identified. The main risk…
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Author(s):
Alberto Lorenzatti
Added:
2 years ago
Author(s):
Esther Godfrey
,
Julian PJ Halcox
Added:
3 years ago
Atherosclerotic cardiovascular disease (CVD) is a global epidemic. As life expectancy has increased, chronic degenerative diseases have become a significant healthcare burden, affecting developed and developing countries alike,1 with atherosclerotic disease the leading cause of death according to the WHO.2 The development of effective strategies for the prevention of cardiovascular events at…
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Author(s):
Alberto Lorenzatti
,
Peter P Toth
Added:
3 years ago
We are witnessing an epidemic global increase in the prevalence of obesity and its clinical consequences (e.g. insulin resistance and diabetes). This epidemic has been potentiated and sustained by the widespread adoption of unhealthy lifestyles in broad swathes of the population and is characterised by a sedentary lifestyle and an imbalance between the type and characteristics of nutrition,…
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Foreword
Author(s):
Cesare Rusconi
Added:
3 years ago
Article
Author(s):
Alberto Lorenzatti
,
Maria Luz Servato
Added:
3 years ago
Coronary artery disease (CAD) is the leading cause of death in most countries. Compelling evidence from epidemiological, genetic and clinical studies as well as experiments in animal models has unquestionably established that elevated concentrations of cholesterol (mainly transported by LDL particles) promote atherosclerotic lesions.1 Although statin-based lipid-lowering therapies have been shown…
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Author(s):
Natalie Arnold
,
Katharina Lechner
,
Christoph Waldeyer
,
et al
Added:
2 years ago