Search results

Filters
Close
ADDED DATE
Added date
AUTHOR Please select
TOPICS Please select
WATCH / LISTEN / READ TIME
Author(s): Sasha Koul , David Erlinge Added: 3 years ago
Acute coronary syndromes (ACS) are a major reason for death and morbidity in the industrialised world. One of the most successful treatments for ACS has been strategies to target the platelets and inhibit their function. Mechanisms of Platelet Activation Thrombus formation in the arteries is dependent on platelets and their ability to attach to the injured wall despite the rapid arterial blood… View more

Anticoagulation

MI/ACS
Author(s): Suzanne J Baron , Robert P Giugliano Added: 3 years ago
Coronary artery disease remains the leading cause of death in the US and worldwide. Although the incidence of death due to coronary artery disease has declined over the last several years, the prevalence of coronary artery disease remains high, with the American Heart Association (AHA) estimating that over 81 million Americans suffer from cardiovascular disease and 2,200 people dying every day of… View more

Anticoagulation
Author(s): Thomas O Bergmeijer , Jochem Wouter van Werkum , Udaya S Tantry , et al Added: 3 years ago
Coronary angiography and subsequent percutaneous coronary intervention (PCI) is the appropriate treatment in many patients with moderate- and high-risk acute coronary syndromes (ACS). As ACS and complications after PCI are primarily platelet-driven, adequate antiplatelet therapy is of utmost importance in patients with ACS and after coronary stent implantation. The main antiplatelet agents… View more

Anticoagulation

Imaging & Diagnostics
Author(s): Marianne Yngen Added: 3 years ago
Introduction Diabetes mellitus (DM), characterised by chronic hyperglycaemia, is a rapidly growing worldwide health problem. The prevalence of DM has been estimated at 3% to 5% of Western populations. The incidence of DM is increasing and will more than double within 15 years, mainly due to adverse lifestyle changes with excess caloric intake and reduced physical activity, which in turn will… View more

Prevention & Chronic Conditions
Summary of Current Guidelines Recommendations for Antithrombotic Therapy
Author(s): Christopher N Floyd Added: 3 years ago
Antiplatelet therapy represents a key pharmacological pillar for the prevention of atherothrombotic events. Aspirin, the primogenial antiplatelet agent, has been shown to reduce the incidence of recurrent major adverse cardiovascular events (MACE) by approximately one-fifth.1 Dual antiplatelet therapy (DAPT), usually aspirin in combination with a P2Y12 inhibitor, provides greater platelet… View more

Anticoagulation

Standards & Guidelines
Author(s): Carlo Patrono Added: 3 years ago
In the Cardiology Masters section of European Cardiology Review we bring you an insight into the career of a key contributor to the field of cardiology. In this edition, we feature Professor Carlo Patrono, Adjunct Professor of Pharmacology at the Catholic University School of Medicine in Rome, Italy, and at the Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA. I was 17… View more

Prevention & Chronic Conditions

MI/ACS
Author(s): Laurent Bonello Added: 3 years ago
Clopidogrel is a key antiplatelet agent that inhibits the second step of platelet aggregation through blockade of the P2Y12-adenosine diphosphate (ADP) receptor.1 Its use has enabled percutaneous coronary intervention (PCI) to expand by dramatically reducing thrombotic complications in acute coronary syndromes (ACSs).2,3 Since the first report by Jaremo et al. of a large inter-individual… View more

Anticoagulation

MI/ACS
Author(s): Diego Penela , Maríbel Diaz-Ricart , Magda Heras Added: 3 years ago
The usual underlying mechanism of acute coronary syndromes (ACSs) is a thrombotic event caused by the rupture or erosion of an atherosclerotic plaque. In this scenario, platelets and thrombin are key players. Thus, understanding the physiopathology of platelet activation is of paramount importance in the treatment of acute coronary ischaemia. There is ample evidence showing that adequate… View more

Anticoagulation

MI/ACS
Author(s): Kerry Layne , Albert Ferro Added: 3 years ago
Acute coronary syndrome (ACS) is a term used to encompass unstable angina (UA) and myocardial infarction (MI) with or without electrocardiographic (ECG) evidence of ST-segment elevation. Antiplatelet therapy has formed the backbone of ACS management for decades and the drug class continues to evolve as novel agents with increasingly efficacious antiplatelet actions are identified. The main risk… View more

Anticoagulation
2020 APSC Consensus Recommendations on P2Y12 Inhibitor Use
Author(s): Jack Wei Chieh Tan , Derek P Chew , Muhamad Ali SK Abdul Kader , et al Added: 3 years ago

Anticoagulation

Standards & Guidelines