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Author(s):
Pensée Wu
,
Ki Park
,
Martha Gulati
Added:
2 years ago
Author(s):
Rocco Antonio Montone
,
Giulia Iannaccone
,
Maria Chiara Meucci
,
et al
Added:
3 years ago
In December 2019, several cases of interstitial pneumonia of unknown origin were detected in Wuhan, China, and on 9 January 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the causative agent of coronavirus disease 2019 (COVID-19). Within a few weeks, the contagion spread through China and South Korea, and the outbreak rapidly extended worldwide due to…
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Author(s):
Konstantinos Toutouzas
,
Antonios Karanasos
,
Dimitris Tousoulis
Added:
3 years ago
Acute coronary syndromes (ACS) comprise a major cause of morbidity and mortality. The almost-exclusive cause of ACS, including unstable angina, acute myocardial infarction (AMI) with or without ST-segment elevation, and sudden cardiac death, is atherothrombosis. Pilot pathological studies have identified the pathophysiological processes implicated in the destabilisation and thrombosis of…
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Author(s):
Dimitris Tousoulis
,
Evangelos Oikonomou
,
Gerasimos Siasos
,
et al
Added:
3 years ago
Diabetes mellitus (DM) is a group of diseases characterised by metabolic disturbances with increasing prevalence worldwide.1 Individuals with DM present several detrimental micro- and macrovascular complications such as retinopathy, nephropathy, neuropathy, atherosclerosis and coronary heart disease.2,3 Accordingly, efforts for early diagnosis and appropriate management are of ultimate importance…
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Author(s):
Carlos Millán-Rodríguez
,
Carlos Palacios Castelló
,
María de Regla Caballero-Valderrama
,
et al
Added:
3 months ago
Author(s):
Alessandro Pingitore
,
Giorgio Iervasi
,
Francesca Forini
Added:
3 years ago
Cardioprotection includes all methods and mechanisms that lead to the reduction in infarct size, and is thus involved in the evolution of post-ischaemic heart failure (HF). This is a growing research issue since ischaemic heart disease is the leading cause of morbidity and mortality worldwide. A key challenge for these studies is the unravelling of cardioprotection complexities such as the…
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Author(s):
Alberto Lorenzatti
,
Peter P Toth
Added:
3 years ago
We are witnessing an epidemic global increase in the prevalence of obesity and its clinical consequences (e.g. insulin resistance and diabetes). This epidemic has been potentiated and sustained by the widespread adoption of unhealthy lifestyles in broad swathes of the population and is characterised by a sedentary lifestyle and an imbalance between the type and characteristics of nutrition,…
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Author(s):
James L Januzzi
Added:
3 years ago
The use of natriuretic peptide testing has dramatically risen recently, in recognition of the value of these blood tests for assisting in the evaluation of patients with suspected heart failure (HF). B-type natriuretic peptide (BNP) is formed as a consequence of production of a 108-amino-acid precursor peptide that is synthesised within the cardiomyocyte; this 'pro-BNP108' is subsequently cleaved…
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Author(s):
Carlo Catalano
,
Michele Anzidei
,
Daniel Geiger
,
et al
Added:
3 years ago
Systemic atherosclerosis involves all major arterial vessels, including the carotid and intracranial arteries, coronary circulation, thoracic and abdominal aorta, internal iliac arteries, renal arteries and peripheral vasculature. This generalised disease contributes to cardiac ischaemic disease, stroke, limb loss and a range of other illnesses, and is the major cause of morbidity and mortality…
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Author(s):
Peter Kabunga
,
John G Coghlan
Added:
3 years ago
Pulmonary arterial hypertension (PAH) is a devastating disease that without specific therapy is characterised by a progressive increase in pulmonary vascular resistance (PVR), leading to right ventricular failure and ultimately death. Among the conditions associated with PAH, connective tissue disease-associated PAH (CTD-PAH) is linked with the gravest prognosis (one-year survival of 50%) without…
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