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Author(s): Tomomi Akama , Araya Tenghattakorn , Motoharu Yamasaki , et al Added: 3 years ago
Topic: Heart Failure (Basic), Molecular Cardiology Previous studies, including ours, suggest that tumour repressor p53 is activated during somatic cell reprogramming, and efficiency of induced pluripotent stem cell (iPSC) formation is limited through transactivation of p53 target genes leading to apoptosis and cell cycle arrest. Recent studies revealed non-transcriptional effects of p53 on… View more

Heart Failure
Applications for Induced Pluripotent Stem Cells in Disease Modelling and Drug Development for Heart Diseases
Author(s): Shu Nakao , Dai Ihara , Koji Hasegawa , et al Added: 3 years ago
Induced Pluripotent Stem Cells and Their Potential Applications Induced pluripotent stem cells (iPSCs) are generated from somatic cells, such as skin fibroblasts, by ectopic expression of defined reprogramming factors. Within a few years of the first report of the generation of mouse iPSCs, several laboratories reportedly reproduced these cells using other cell types and species using similar… View more

Vascular Disease and Surgery
Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype?
Author(s): Alexandros Protonotarios , Perry Elliott Added: 3 years ago
Until the 20th century, conventional medicine relied almost exclusively on observable characteristics to classify and treat human disease.1 Even in the modern era, physicians define diseases using phenotypic similarities and employ relatively simple algorithms to interpret diagnostic tools and plan treatment. The advent of low-cost genetic sequencing and its introduction into clinical care… View more

Heart Failure
New Advances in the Management of Refractory Angina Pectoris
Author(s): Kevin Cheng , Ranil de Silva Added: 3 years ago
Refractory angina (RA) is defined as chronic angina-type chest pain (duration ≥ 3 months) associated with reversible ischaemia that persists despite optimal medical, interventional and surgical management.1 The clinical burden of RA is growing due to an ageing population and improved survival from coronary artery disease (CAD). Estimates suggest that in the US between 600,000 and 1.8 million… View more

Prevention & Chronic Conditions
Author(s): Daniel Alejandro Lerman , Nasri Alotti , Kiddy Levente Ume , et al Added: 3 years ago
Acute myocardial infarction (AMI) is still a major public health problem worldwide, causing high rates of morbidity and mortality. In the United States, nearly one million patients suffer from AMI each year.1 In the UK, around 80,000 people died from coronary heart disease (CHD) in 2010.2 The current approach to the treatment of myocardial infarction involves early revascularisation with… View more

Vascular Disease and Surgery

Heart Failure
Author(s): Hirohiko Kohjitani , Shigeya Koda , Yukiko Himeno , et al Added: 3 years ago
Topic: Arrhythmia (Basic), Electrophysiology Background Human induced pluripotent stem cells-derived cardiomyocytes (hiPSC-CMs) are expected tool for preclinical evaluation of the safety and efficacy of compounds on the heart. Its action potential (AP) parameters were measured in order to estimate pro-arrhythmic effects of new drugs, mutation of ion-channels, and so on. But, hiPSC-CMs exhibit… View more

Electrophysiology & Arrhythmia
Author(s): Ali Ghodsizad , Mina Farag , Matthias Loebe , et al Added: 3 years ago
It is estimated that approximately 5 million Americans currently live with heart failure (HF) and an additional 500,000 patients are newly diagnosed each year.1 End-stage HF has a worse prognosis than most types of cancer,2 and heart transplantation remains the gold standard of all therapies for advanced HF.3 However, the number of donor organs significantly fails to meet demand. Therefore,… View more

Vascular Disease and Surgery

MI/ACS
Erectile Dysfunction And Ischaemic Heart Disease
Author(s): Abdalla Ibrahim , Mohamed Ali , Thomas J Kiernan , et al Added: 3 years ago
Erectile dysfunction (ED) is generally defined as the persistent (at least 6 months) inability to achieve and maintain penile erection sufficient to allow satisfactory sexual performance.1 It is a common condition, and recent studies predict a higher prevalence of ED in the future.2 It is estimated that ED has affected more than 150 million men worldwide and this number will reach approximately… View more

MI/ACS
Author(s): Gustav Steinhoff Added: 3 years ago
Cell therapy for myocardial regeneration is an exciting new field of medical research that has the potential to revolutionise cardiovascular medicine. Despite significant improvements in emergency treatment, myocardial infarction (MI) leads to a net loss of contractile tissue in many patients with coronary artery disease (CAD). Often, this is the beginning of a downward spiral towards congestive… View more

Vascular Disease and Surgery

MI/ACS
Author(s): Gustav Steinhoff Added: 3 years ago
Cell therapy for myocardial regeneration is an exciting new field of medical research that has the potential to revolutionize cardiovascular medicine. Despite significant improvements in emergency treatment, myocardial infarction leads to a net loss of contractile tissue in many patients with coronary artery disease. Often, this is the beginning of a downward spiral towards congestive heart… View more

Vascular Disease and Surgery