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3 years ago
There has been an increase in the prevalence of diabetes mellitus over the past 40 years, both in the US and worldwide. The worldwide prevalence of diabetes in 2000 was approximately 2.8% and is estimated to grow to 4.4% by 2030. This translates to a projected rise of diabetes from 171 million in 2000 to well over 350 million in 2030. The epidemic of diabetes will continue to rise as there is…
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3 years ago
Atherogenic dyslipidaemia encompasses a broad variety of lipid phenotypes. While LDL cholesterol is a well-known risk factor for atherosclerotic cardiovascular disease (ASCVD), there are additional atherogenic lipoproteins that may be targeted to further reduce ASCVD risk.
In their comprehensive review, Lorenzatti and Toth emphasise that, even when LDL cholesterol levels are optimised, ASCVD…
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3 years ago
Cell therapy for myocardial regeneration is an exciting new field of medical research that has the potential to revolutionise cardiovascular medicine. Despite significant improvements in emergency treatment, myocardial infarction (MI) leads to a net loss of contractile tissue in many patients with coronary artery disease (CAD). Often, this is the beginning of a downward spiral towards congestive…
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3 years ago
The greatest burden of cardiovascular disease (CVD) is due to non-fatal morbidity and its consequences; whereas CVD accounts for approximately 17 million deaths each year worldwide, current estimates indicate that CVD associated with asymptomatic disease and target organ damage as a result of undetected cardiovascular risk factors affects 128 million people worldwide.1,2 Moreover, the worldwide…
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3 years ago
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3 years ago
Cardiac resynchronisation therapy (CRT) has been a cornerstone in the treatment of select advanced heart failure cases since its introduction to our armamentarium in the early 2000s.1 Indeed, 30–60% of advanced heart failure patients exhibit evidence of dyssynchrony, when defined electrocardiographically or mechanically.2–4 The latter is a consequence of the former. CRT has several unique…
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3 years ago
Cardiac surgery is associated with a significant risk of morbidity and mortality. In the UK, over 30,000 patients per year undergo cardiac surgery, with a hospital mortality of approximately 2.5% for coronary artery bypass grafting (CABG). Other procedures, such as cardiac valve surgery, may have higher mortality rates. Cardiac surgery is also associated with major morbidities, such as stroke,…
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3 years ago
A 65-year-old male patient was referred to our outpatient clinic for cardiac evaluation because of an asymptomatic continuous murmur. Four years ago, a grade 2/6 systolic cardiac murmur had been coincidentally detected, but it had not been investigated so far. The patient was completely asymptomatic. There was no relevant past medical history or significant family history. His cardiovascular risk…
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3 years ago
Congenital heart disease is the most common congenital malformation and accounts for about eight cases per 1,000 births.1 Due to tremendous developments in cardiac surgery, nearly 90% of all children with congenital heart disease reach adult age. In patients with congenital heart disease, pulmonary arterial hypertension (PAH) may develop due to increased pulmonary arterial flow as a result of a…
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The TALENT Study
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3 years ago
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