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TBL1 Suppresses Cardiomyocyte Hypertrophy by Regulating the Interaction Between HDAC3 and GATA4
Author(s):
Yasufumi Katanasaka
,
Masatoshi Namiki
,
Yoichi Sunagawa
,
et al
Added:
3 years ago
Article
Mechanisms of Cardiotoxicity Associated with Tyrosine Kinase Inhibitors in H9c2 Cells and Mice
Author(s):
J Bouitbir
,
A Alshaikhali
,
M Panajatovic
,
et al
Added:
3 years ago
Article
Author(s):
Alberto Balbarini
,
Rossella Di Stefano
Added:
3 years ago
Since endothelial damage and dysfunction play a critical role in atherosclerotic disease, research interest has aimed at evaluating the role of endothelial progenitor cells (EPCs) in vascular endothelial layer maintenance. In contrast to local resident endothelial cells, which have a poor proliferative rate, the regenerative capacity of EPCs and their ability to integrate into blood vessels have…
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Author(s):
Tomomi Akama
,
Araya Tenghattakorn
,
Motoharu Yamasaki
,
et al
Added:
3 years ago
Topic: Heart Failure (Basic), Molecular Cardiology
Previous studies, including ours, suggest that tumour repressor p53 is activated during somatic cell reprogramming, and efficiency of induced pluripotent stem cell (iPSC) formation is limited through transactivation of p53 target genes leading to apoptosis and cell cycle arrest. Recent studies revealed non-transcriptional effects of p53 on…
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Application of CD271+ Human Bone Marrow-derived Stem Cells for Ischaemic Heart Disease Therapy
Author(s):
Ali Ghodsizad
,
Mina Farag
,
Matthias Loebe
,
et al
Added:
3 years ago
Article
Author(s):
Shu Nakao
,
Dai Ihara
,
Koji Hasegawa
,
et al
Added:
3 years ago
Induced Pluripotent Stem Cells and Their Potential Applications
Induced pluripotent stem cells (iPSCs) are generated from somatic cells, such as skin fibroblasts, by ectopic expression of defined reprogramming factors. Within a few years of the first report of the generation of mouse iPSCs, several laboratories reportedly reproduced these cells using other cell types and species using similar…
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Author(s):
Nilofer Sorathia
,
Hussein Al-Rubaye
,
Benham Zal
Added:
3 years ago
Statins are most frequently prescribed for the primary prevention of cardiovascular disease due to their lipid-lowering properties. They are known to exert their effect by competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. The reduction in the synthesis of cholesterol induces upregulation of LDL receptors in the liver, resulting in increased clearance and…
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Author(s):
Gustav Steinhoff
Added:
3 years ago
Cell therapy for myocardial regeneration is an exciting new field of medical research that has the potential to revolutionise cardiovascular medicine. Despite significant improvements in emergency treatment, myocardial infarction (MI) leads to a net loss of contractile tissue in many patients with coronary artery disease (CAD). Often, this is the beginning of a downward spiral towards congestive…
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Author(s):
Hans-Michael Klein
Added:
3 years ago
An increasing number of patients survive acute myocardial infarction. Surgical and interventional revascularisation of the ischaemic myocardium can treat angina, reduce risk of myocardial infarction and improve the function of the viable myocardium. However, the therapeutic possibilities in end-stage heart failure patients are limited. This article investigates alternative treatment options such…
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