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Author(s): Yasufumi Katanasaka , Masatoshi Namiki , Yoichi Sunagawa , et al Added: 3 years ago
Topic: Heart Failure (Basic), Molecular Cardiology Cardiac hypertrophy is a risk factor for the development of heart failure. To elucidate underlying molecular mechanism is necessary for the development of novel pharmacological therapy targeting to pathological cardiac hypertrophy. We have previously reported that the acetylation of GATA4 by p300 is essential for cardiomyocyte hypertrophy and… View more

Heart Failure
Author(s): Satoshi Shimizu , Yoichi Sunagawa , Kodai Hara , et al Added: 3 years ago
Topic: Heart Failure (Basic), Molecular Cardiology Introduction The zinc finger protein GATA4 is a transcription factor that associates with the intrinsic histone acetyltransferase p300 and regulates myocardial transcriptional activity in response to hypertrophic stimuli. It is known that GATA1, another member of the GATA transcription family, forms a homo-dimer and regulates transcriptional… View more

Heart Failure
The Role of C-reactive Protein in Patient Risk Stratification and Treatment
Author(s): Ramón Arroyo-Espliguero , María Carmen Viana-Llamas , Alberto Silva-Obregón , et al Added: 2 years ago

Prevention & Chronic Conditions
ACC.24: The LIBerate-CVD Trial
Author(s): Evan A Stein Added: 1 week ago
ACC.24 — We are joined onsite by investigator, Dr Evan A Stein (Medpace Reference Laboratories, US) to discuss the findings from the LIBerate-CVD trial (NCT04797247).LIBerate-CVD investigated LDL-C reductions in a cohort of 900 patients with cardiovascular diseases and hyper-LDL-cholesterol treated with 300mg subcutaneous Lerodalcibep as compared to placebo across a 52-week treatment period… View more

Prevention & Chronic Conditions
Author(s): Yoichi Sunagawa , Masafumi Funamoto , Anna Suzuki , et al Added: 3 years ago
Topic: 3. Heart Failure and Cardiomyopathy Introduction and Objectives Maladaptive hypertrophy is being recognized as a critical event during the development of heart failure. In a previous study, we demonstrated that a natural compound, curcumin, prevented cardiomyocyte hypertrophy and the development of heart failure in two different model animals.1–4 Recently, we screened a natural… View more

Heart Failure
Author(s): Hiroshi Watanabe Added: 3 years ago
Pulmonary arterial hypertension (PAH) is a chronic and life-threatening disease characterised by progressive vascular remodelling that leads to increased pulmonary vascular resistance, right ventricular heart failure and death. PAH is defined by >25 mmHg increase in pulmonary arterial blood pressure and a pulmonary capillary wedge pressure of 15 mmHg.1 If left untreated PAH is fatal; it has a… View more

Prevention & Chronic Conditions
Author(s): Reynaria N Pitts , Robert Eckel Added: 3 years ago
Elevated levels of low-density lipoprotein cholesterol (LDL-C) have long been established as one of the most important risk factors for developing coronary artery disease (CAD) and other forms of atherosclerotic cardiovascular disease (CVD).1,2 Targeting LDL-C reduction has been effective in lowering cardiovascular risk.3,4 The use of HMGCoA reductase inhibitors (statins) for both primary and… View more

Prevention & Chronic Conditions
Author(s): Peter Hunold , Jörg Barkhausen Added: 3 years ago
There are many things in life everybody wants more of, and this is particularly true for magnetic resonance imaging (MRI). The major challenge in the daily life of an MRI professional is gaining maximal image signal and contrast in a reasonable amount of time. The application of gadolinium (Gd)-based MR contrast material has offered contrast features in MRI that have been used and appreciated for… View more

Imaging & Diagnostics
Author(s): Antonio J Vallejo-Vaz Added: 3 years ago
Heart Failure – A Major Global Health Problem Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality in developed countries and its burden is progressively increasing.1–4 Coronary artery disease (CAD) and other conditions, such as hypertensive heart disease or diabetes mellitus, are rated among the foremost reasons for morbi-mortality worldwide.1–4 In this context,… View more

Imaging & Diagnostics

Heart Failure
ESC 23: LIBerate-HeFH Study
Author(s): Frederick Raal Added: 7 months ago
ESC 23 — Prof Frederick Raal (University of the Witwatersrand, Johannesburg, SA) outlines the late-breaking results from the LIBerte-HeFH study (NCT04797104). The phase III LIBerte-HeFH study (LIB Therapeutics LLC) aimed to assess the effectiveness of PCSK9-inhibitor Ierodalcibep (LIB003) in reducing low-density lipoprotein cholesterol (LDL-C) in 300mg doses administered subcutaneously in… View more

Heterogeneous Populations

Prevention & Chronic Conditions