Search results
Author(s):
Cameron T Lambert
,
Pratik Sandesara
,
Ijeoma Isiadinso
,
et al
Added:
3 years ago
Familial hypercholesterolaemia (FH) is an autosomal-dominant disorder associated with mutations in the LDL receptor (LDLR) gene resulting in markedly elevated plasma low-density lipoprotein cholesterol (LDL-C) levels and premature atherosclerotic cardiovascular disease (ASCVD). Heterozygous FH (HeFH) (mutation in one allele) is associated with plasma LDL-C levels >190 mg/dl, whereas homozygous…
View more
Author(s):
Rodrigo Alonso
,
Leopoldo Perez de Isla
,
Ovidio Muñiz-Grijalvo
,
et al
Added:
3 years ago
Familial hypercholesterolaemia (FH) is the genetic disorder most commonly associated with elevated LDL cholesterol (LDL-C) levels from birth and with premature atherosclerotic cardiovascular disease (ASCVD).1 It is caused by mutations in genes related to the clearance of LDLs such as LDL receptor (LDLR), apolipoprotein B-100 (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9).2 The…
View more
Author(s):
Antonio J Vallejo-Vaz
Added:
3 years ago
Elevated LDL cholesterol (LDL-C) plays a major role in the development of atherosclerotic cardiovascular disease (ASCVD). Multiple studies and meta-analyses, including randomised controlled trials, prospective cohort studies and Mendelian randomisation studies, have consistently shown an association between LDL-C and ASCVD risk that is proportional to the magnitude and duration of exposure to…
View more
Author(s):
Stephen J Nicholls
Added:
3 years ago
Therapeutic targeting of dyslipidaemia has been one of the major successes in cardiovascular medicine over the last three decades. On the basis of unequivocal evidence from animal models through to both population and genetic studies in humans, there is a clear association between increasing levels of LDL cholesterol (LDL-C) and incident cardiovascular risk.1 This has prompted efforts to develop…
View more
Author(s):
Robert Dalla Pozza
,
Susanne Bechtold
Added:
3 years ago
Atherosclerosis and atherosclerosis-related complications such as coronary, cerebrovascular and peripheral arterial disease show their clinical manifestation in adulthood. However, changes at the endothelial level do not occur suddenly in the elderly, but are the result of a long, on-going, slowly evolving process. We know from autopsy studies that atherosclerotic processes begin in childhood and…
View more
Author(s):
Natalie Koh
,
Brian Ference
,
Stephen J Nicholls
,
et al
Added:
2 years ago
Author(s):
Helena Gylling
,
Tatu A Miettinen
Added:
3 years ago
Plant stanols and plant sterols are normal components of plants, and they are present in normal food; approximately 30mg of plant stanols and about 300mg of plant sterols are present in normal daily food. Vegetable oils, especially corn oil, soybean oil, and rapeseed oil, are rich especially in plant sterols, but they also contain small amounts of plant stanols. Plant stanols differ in their…
View more
Foreword
Author(s):
Juan Carlos Kaski
Added:
3 years ago
Article
Author(s):
Reynaria N Pitts
,
Robert Eckel
Added:
3 years ago
Elevated levels of low-density lipoprotein cholesterol (LDL-C) have long been established as one of the most important risk factors for developing coronary artery disease (CAD) and other forms of atherosclerotic cardiovascular disease (CVD).1,2 Targeting LDL-C reduction has been effective in lowering cardiovascular risk.3,4 The use of HMGCoA reductase inhibitors (statins) for both primary and…
View more
Dyslipidaemia in the Real World
Author(s):
Ricardo Lopez Santi
,
Felipe Martínez
,
Adrian Baranchuk
,
et al
Added:
2 years ago
Article