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Dyspnoea in Oncological Patients
Author(s):
Kalliopi Keramida
,
Athanasios Kostoulas
Added:
1 year ago
Article
Author(s):
James L Januzzi
Added:
3 years ago
The use of natriuretic peptide testing has dramatically risen recently, in recognition of the value of these blood tests for assisting in the evaluation of patients with suspected heart failure (HF). B-type natriuretic peptide (BNP) is formed as a consequence of production of a 108-amino-acid precursor peptide that is synthesised within the cardiomyocyte; this 'pro-BNP108' is subsequently cleaved…
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Author(s):
Christopher R deFilippi
,
G Michael Felker
Added:
3 years ago
Biomarkers have become central to the management of cardiovascular disease, and their potential clinical applications continue to grow. This article reviews galectin-3 (Gal-3), a novel biomarker of fibrosis and remodeling, and its clinical application in heart failure (HF).
Case Studies
Case Study One
A 63-year-old African-American female presents to the emergency department with acute dyspnea…
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Author(s):
Christian Müller
Added:
3 years ago
B-type natriuretic peptide (BNP) and N-terminal prohormone brain natriuretic peptide (NT-proBNP) have been shown to be extremely helpful in the diagnosis and management of patients with heart failure (HF). These neurohormones are secreted from both the left and the right cardiac ventricle in response to ventricular volume expansion and pressure overload. BNP and NT-proBNP can be seen as…
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C Noel Bairey Merz
Research Area(s) / Expertise:
Job title: Cardiologist
Author
B-type Natriuretic Peptides in the Management of Acute Heart Failure and Acute Coronary Syndromes
Author(s):
Torbjørn Omland
Added:
3 years ago
Article
Author(s):
Johannes Mair
Added:
3 years ago
In 1981, de Bold et al.1 provided the definitive demonstration of the endocrine function of the heart by the description of atrial natriuretic peptide (ANP). This was followed by the identification of brain natriuretic peptide, or B-type natriuretic peptide (BNP), in 1988.2,3 This natriuretic peptide (NP) was originally discovered in the porcine brain, but it is synthesised, stored and released…
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Author(s):
Antonio J Vallejo-Vaz
Added:
3 years ago
Heart Failure – A Major Global Health Problem
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality in developed countries and its burden is progressively increasing.1–4 Coronary artery disease (CAD) and other conditions, such as hypertensive heart disease or diabetes mellitus, are rated among the foremost reasons for morbi-mortality worldwide.1–4 In this context,…
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Author(s):
Joanne D Schuijf
,
Jeroen J Bax
,
Ernst E van der Wall
Added:
3 years ago
Diabetes is an important risk factor for coronary artery disease (CAD) as reflected by the four-fold greater incidence of CAD in diabetic patients compared with the general population.1 Cardiovascular death is the most common cause of mortality in the type 2 diabetic population and, once diagnosed with CAD, patients with diabetes have a considerably poorer prognosis than their non-diabetic…
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Author(s):
Diego Penela
,
Maríbel Diaz-Ricart
,
Magda Heras
Added:
3 years ago
The usual underlying mechanism of acute coronary syndromes (ACSs) is a thrombotic event caused by the rupture or erosion of an atherosclerotic plaque. In this scenario, platelets and thrombin are key players. Thus, understanding the physiopathology of platelet activation is of paramount importance in the treatment of acute coronary ischaemia. There is ample evidence showing that adequate…
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