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Author(s):
Alexandros Protonotarios
,
Perry Elliott
Added:
3 years ago
Until the 20th century, conventional medicine relied almost exclusively on observable characteristics to classify and treat human disease.1 Even in the modern era, physicians define diseases using phenotypic similarities and employ relatively simple algorithms to interpret diagnostic tools and plan treatment. The advent of low-cost genetic sequencing and its introduction into clinical care…
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Francis E Marchlinski
Job title: Director of Electrophysiology Laboratory
Author
Author(s):
Afik D Snir
,
Hariharan Raju
Added:
3 years ago
Brugada syndrome was first described in 1993 in a case series of eight patients with recurrent polymorphic ventricular tachycardia (VT) and stereotypical electrographic characteristics in the context of a structurally normal heart.1 Since then, the syndrome has been extensively studied and recognised worldwide as a major cause of sudden cardiac death (SCD) in otherwise healthy patients.2 Recent…
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Author(s):
Luokai Wang
,
Tee Joo Yeo
,
Benedict Tan
,
et al
Added:
2 years ago
Author(s):
Velislav N Batchvarov
Added:
3 years ago
Introduction
The Brugada syndrome (BrS) is a hereditary arrhythmia syndrome manifesting as recurrent syncope or sudden cardiac death (SCD) due to polymorphic ventricular (VT) or fibrillation (VF) in the absence of overt structural heart disease or myocardial ischaemia.1,2 The prevalence of the syndrome is estimated at around 15 per 10,000 in South East Asia including Japan and around 2 per 10,000…
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Author(s):
Alexandros Klavdios Steriotis
,
Sanjay Sharma
Added:
3 years ago
Hypertrophic cardiomyopathy (HCM) is a hereditary primary myocardial disease that is most commonly caused by mutations within genes encoding sarcomeric contractile proteins and is characterised by left ventricular hypertrophy in the absence of a cardiac or systemic cause.1,2 The condition is inherited as an autosomal dominant trait and has a prevalence of one in 500.3,4 Marked genetic…
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Author(s):
Aneil Malhotra
,
Sanjay Sharma
Added:
3 years ago
Athletes who perform regular and intensive exercise regimes develop a variety of electrical and structural cardiac adaptations that manifest functionally to improve stroke volume and performance. Up to one-fifth of young athletes (aged between 14–35 years) reveal greater left ventricular (LV) wall thickness compared to sedentary controls, though the majority fall under 12 mm.1,2 A small…
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Author(s):
Vincent Floré
,
Rik Willems
Added:
3 years ago
Sudden cardiac arrest (SCA) can be defined as the abrupt cessation of cardiac activity due to an underlying cardiac cause, occurring instantaneously in a previously stable patient and in the absence of non-cardiovascular causes (e.g., trauma, intoxication, drowning, electrocution).1,2 SCA will lead to loss of consciousness within the minute due to insufficient cerebral perfusion. If no immediate…
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Author(s):
Gianfranco Sinagra
,
Michele Moretti
,
Giancarlo Vitrella
,
et al
Added:
3 years ago
According to the latest position statement of the European Society of Cardiology (ESC), cardiomyopathies (CMP) are defined as “myocardial disorders in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disease sufficient to cause the observed myocardial abnormality”.1
CMP may be…
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